Top 24 Inflammatory Disease Startups

Updated: Mar 19, 2026
|
These startups develop new technologies to treat inflammatory diseases: biomarker identification, high-throughput screening, targeted biologic therapies, AI imaging techniques, nanotechnology applications, immunomodulatory drugs, telehealth solutions.
1
SetPoint Medical
Country: USA | Funding: $496.4M
SetPoint Medical treats patients with debilitating inflammatory diseases using proprietary implantable bioelectronic devices.
2
Apogee Therapeutics
Country: USA | Funding: $997M
Apogee Therapeutics operates pipeline candidates designed to treat inflammatory and immunological disorders.
3
Nimbus Therapeutics
Country: USA | Funding: $637M
Nimbus Therapeutics is pioneering a new computational technology-driven paradigm to rapidly advance a diverse pipeline of novel small molecule product candidates into clinical development. We are designing highly selective and potent medicines to disrupt known drivers of serious diseases, including metabolic disease, cancer and immune-inflammatory disorders.
4
Acelyrin
Country: USA | Funding: $558M
ACELYRIN is a biopharma company that identifies, acquires, and accelerates the development and commercialization of life-changing inflammatory-disease-focused therapies.
5
Ventyx Biosciences
Country: USA | Funding: $468.6M
Ventyx Biosciences develops a drug for inflammatory bowel disease
6
Harbour BioMed
Country: China | Funding: $417.8M
Harbour BioMed is a global biopharmaceutical company developing innovative therapeutics in the field of immuno-oncology and inflammatory diseases.
7
Evelo Biosciences
Country: USA | Funding: $397M
Evelo is pioneering therapies that modulate systemic immune response by acting on the gut-body network - monoclonal microbials. They have the potential to treat many diseases, including inflammatory disease, cancer, autoimmune disease, metabolic, neurobehavior and neuroinflammatory diseases.
8
Aviceda Therapeutics
Country: USA | Funding: $276.8M
Aviceda Therapeutics is a late-stage, pre-clinical biotech company developing drugs for treating glyco-immune diseases.
9
Escient Pharmaceuticals
Country: USA | Funding: $237.5M
Escient Pharmaceuticals is a provider of bio-technical research and development services intended to focus in advancement of first-in-class G Protein-Coupled Receptor targeted drugs. The company's services focuses on offering therapies for neuro-immuno-inflammatory and autoreactive diseases
10
Triveni Bio
Country: USA | Funding: $207M
Triveni Bio focuses on the identification of novel disease by combining human genetics and precision medicine.
11
Connect Biopharma
Country: China | Funding: $195M
Connect Biopharmaceuticals is a developer of novel immune modulators for the treatment of serious autoimmune diseases and inflammation.
12
Santa Ana Bio
Country: USA | Funding: $176M
Santa Ana Bio is a biotechnology company focusing on precision immunology for autoimmune and inflammatory diseases.
13
NorthSea Therapeutics
Country: Netherlands | Funding: $149.4M
NorthSea Therapeutics is a biotech company developing first-in class, oral, structurally-engineered lipid therapeutics targeting metabolic, inflammatory and fibrotic diseases. The SEFA technology has generated pipeline candidates with a broad array of inter- and independent biological effects, improving dyslipidemia, insulin resistance, hepatic inflammation and fibrosis in diverse models.
14
Ashvattha Therapeutics
Country: USA | Funding: $148M
Ashvattha Therapeutics develops therapy thar selectively targets hyper-inflammatory macrophages responsible for excessive cytokine production in severe COVID-19 patients.
15
Cour Pharmaceutical
Country: USA | Funding: $135.5M
The Cour particle platforms provide a novel and highly specific immune targeting capability which may be safely applied to severe inflammatory modulation, and immune (antigen) tolerization.
16
Genkyotex
Country: Switzerland | Funding: $87.1M
Genkyotex is the leading developer of NOX inhibitors. We are developing first-in-class, small molecule therapeutics that selectively inhibit NOX enzymes. NOX enzymes are key drivers in multiple diseases including fibrotic, inflammatory, cardiovascular and CNS diseases and oncology.
17
GeNeuro
Country: Switzerland | Funding: $54.6M
GeNeuro develops innovative treatments against inflammatory and degenerative disorders associated with endogenous retroviruses.
18
PureTech Health
Country: USA | Funding: $11.4M
PureTech Health is developing differentiated medicines for devastating diseases including intractable cancers, lymphatic and GI diseases, CNS disorders and inflammatory and immunological diseases
19
Ilias Biologics
Country: South Korea | Funding: $37.6M
Ilias Biologics is developing various therapeutic exosomes, a potential treatment for sepsis, pre-term birth, and various hard-to-treat diseases in inflammatory and metabolic areas.
20
Exeliom Biosciences
Country: France | Funding: €22.3M
Exeliom Biosciences develops a bacterial treatment for inflammatory bowel diseases. It's intended to rebalance the gut microbiome through the delivery of Faecalibacterium prausnitzii, one of the most abundant species of bacteria in the gut.
21
Aqualung Therapeutic
Country: USA | Funding: $22.3M
Aqualung Therapeutics is developing a novel, anti-inflammatory monoclonal antibody strategy to treat serious unchecked inflammation.
22
Zest Health
Country: USA | Funding: $13M
Value based care platform focused on treating patients with inflammatory skin diseases
23
SFA Therapeutics
Country: USA | Funding: $8.7M
SFA Therapeutics, LLC is a development-stage bio-pharmaceutical startup company focused on a new advancement in the treatment of chronic inflammatory disease - the use of microbiome-derived metabolites as drugs.
24
Exosomm
Country: Israel | Funding: $3.9M
Exosomm develops food solutions based on natural milk exosomes. Exosomm’s first product is a food formula with a patented-based active anti-inflammatory effect designed for patients with inflammatory bowel diseases (Crohn´s & Colitis).
  See also:
Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com