Top 223 medical and healthcare startups in San Francisco
Jan 29, 2026
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21
1
Funding: $72M
Link Cell Therapies develops CAR-T cell therapies for patients with solid tumors. The company has developed unique AND gate technology that requires co-expression of cancer targets to ensure cellular cytotoxicity and greater tumor specificity. It enables safe targeting of multiple antigens that are co-expressed on cancer cells but have no or minimal overlap in normal healthy tissue. Combined with additional platforms in development, the company is advancing number of promising therapeutic programs that promise to unlock the potential of CAR T therapy in a variety of important oncological diseases, including solid tumors and certain hematological malignancies. Johnson & Johnson is a major investor in the startup.
Link Cell Therapies develops CAR-T cell therapies for patients with solid tumors. The company has developed unique AND gate technology that requires co-expression of cancer targets to ensure cellular cytotoxicity and greater tumor specificity. It enables safe targeting of multiple antigens that are co-expressed on cancer cells but have no or minimal overlap in normal healthy tissue. Combined with additional platforms in development, the company is advancing number of promising therapeutic programs that promise to unlock the potential of CAR T therapy in a variety of important oncological diseases, including solid tumors and certain hematological malignancies. Johnson & Johnson is a major investor in the startup.
2
Funding: $31.3M
WearLinq produces wearable devices for health monitoring and diagnostics, in particular wireless 6-lead clinical ECG monitor and monitor eWave. It pairs with user's phone, transmitting real-time data and reports for up to 48 hours to doctors. The company claims the wireless monitor can last more than five days on a single charge. The device can help detect arrhythmias, but the company plans to expand its use in the future. WearLinq already received FDA clearance for the device to continuously monitor cardiac activity in individuals who may be asymptomatic or experience transient symptoms such as syncope, palpitations, dizziness, shortness of breath, lightheadedness, weakness, fatigue or anxiety.
WearLinq produces wearable devices for health monitoring and diagnostics, in particular wireless 6-lead clinical ECG monitor and monitor eWave. It pairs with user's phone, transmitting real-time data and reports for up to 48 hours to doctors. The company claims the wireless monitor can last more than five days on a single charge. The device can help detect arrhythmias, but the company plans to expand its use in the future. WearLinq already received FDA clearance for the device to continuously monitor cardiac activity in individuals who may be asymptomatic or experience transient symptoms such as syncope, palpitations, dizziness, shortness of breath, lightheadedness, weakness, fatigue or anxiety.
3
Funding: $231M
Chai Discovery develops AI models that predict and reprogram biochemical molecule interactions. Chai’s goal is to shorten the drug development timeline so that potential new medicines enter first-in-human studies and reach the market quicker. It can design molecules that have needed properties and tackle challenging targets that have been out of reach. The team has already used its flagship model Chai 2 to develop monoclonal antibodies aimed against tough-to-drug targets, and (accoring to the company) the new designs have properties similar to known antibody drugs.
Chai Discovery develops AI models that predict and reprogram biochemical molecule interactions. Chai’s goal is to shorten the drug development timeline so that potential new medicines enter first-in-human studies and reach the market quicker. It can design molecules that have needed properties and tackle challenging targets that have been out of reach. The team has already used its flagship model Chai 2 to develop monoclonal antibodies aimed against tough-to-drug targets, and (accoring to the company) the new designs have properties similar to known antibody drugs.
4
Funding: $3B
Altos Labs is working on biological reprogramming technology to essentially prolong human life
Altos Labs is working on biological reprogramming technology to essentially prolong human life
5
Funding: $2.4B
Cytokinetics develops first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised.
Cytokinetics develops first-in-class muscle activators as potential treatments for debilitating diseases in which muscle performance is compromised.
6
Funding: $1.5B
Calico is Google's research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
Calico is Google's research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.
7
Funding: $1.5B
Freenome is a platform that helps design healthy conditions for an individual based on his/her cell-free genome. It employs Artificial Intelligence to detect colorectal cancer.
Freenome is a platform that helps design healthy conditions for an individual based on his/her cell-free genome. It employs Artificial Intelligence to detect colorectal cancer.
8
Funding: $1.1B
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
9
Funding: $1.1B
Retro Biosciences focus on cellular reprogramming, autophagy and plasma-inspired therapeutics.
Retro Biosciences focus on cellular reprogramming, autophagy and plasma-inspired therapeutics.
10
Funding: $1B
Allogene Therapeutics is working to overcome the limitations of autologous CAR T therapy by creating allogeneic CAR T cell (AlloCAR T) products that utilize T cells from healthy donors. These cells are isolated in a manufacturing facility, engineered to express CAR T cells (that recognize and destroy disease) and genetically modified to limit the autoimmune response when administered to a patient. These cells are then stored for use as needed. The company estimates that a single production cycle is sufficient to treat over 100 patients, significantly reducing the cost of therapy. The company's pipeline includes candidates for large B-cell lymphoma and renal cell carcinoma (ALLO-316 is the first and only allogeneic CAR T cell therapy to show promising results in the treatment of solid tumors). The company operates its own manufacturing complex for clinical and commercial production, analytical testing and distribution of cell products.
Allogene Therapeutics is working to overcome the limitations of autologous CAR T therapy by creating allogeneic CAR T cell (AlloCAR T) products that utilize T cells from healthy donors. These cells are isolated in a manufacturing facility, engineered to express CAR T cells (that recognize and destroy disease) and genetically modified to limit the autoimmune response when administered to a patient. These cells are then stored for use as needed. The company estimates that a single production cycle is sufficient to treat over 100 patients, significantly reducing the cost of therapy. The company's pipeline includes candidates for large B-cell lymphoma and renal cell carcinoma (ALLO-316 is the first and only allogeneic CAR T cell therapy to show promising results in the treatment of solid tumors). The company operates its own manufacturing complex for clinical and commercial production, analytical testing and distribution of cell products.
11
Funding: $1B
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
12
Funding: $1B
Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence.
Xaira Therapeutics is an integrated biotechnology company driving advances in artificial intelligence.
13
Funding: $971M
Zipline designs, manufactures, and operates drones to deliver vital medical products.
Zipline designs, manufactures, and operates drones to deliver vital medical products.
14
Funding: $908.6M
Vir Biotechnology brings together cutting-edge innovations with scientific expertise and management.
Vir Biotechnology brings together cutting-edge innovations with scientific expertise and management.
15
Funding: $905M
Transcarent is a consumer-directed health and care company for employees of self-insured employers and their families.
Transcarent is a consumer-directed health and care company for employees of self-insured employers and their families.
17
Funding: $700M
Odyssey Therapeutics is a computational immunology company that develops novel therapeutics for patients with autoimmune diseases.
Odyssey Therapeutics is a computational immunology company that develops novel therapeutics for patients with autoimmune diseases.
18
Funding: $680M
Alto Pharmacy operates an online retail platform for prescription drugs.
Alto Pharmacy operates an online retail platform for prescription drugs.
19
Funding: $654.1M
Innovaccer is a leading healthcare data activation company committed to making powerful & enduring difference in the way care is delivered.
Innovaccer is a leading healthcare data activation company committed to making powerful & enduring difference in the way care is delivered.
20
Funding: $654.1M
With it's Big Data platform 'InData', Innovaccer is helping large healthcare organizations to adopt data driven healthcare operations and transform into the value-based care world.
With it's Big Data platform 'InData', Innovaccer is helping large healthcare organizations to adopt data driven healthcare operations and transform into the value-based care world.
21
Funding: $652M
Apogee Therapeutics operates pipeline candidates designed to treat inflammatory and immunological disorders.
Apogee Therapeutics operates pipeline candidates designed to treat inflammatory and immunological disorders.
22
Funding: $646M
Maze Therapeutics is a operator of a biotechnology firm intended to focused on translating genetic insights into new medicines.
Maze Therapeutics is a operator of a biotechnology firm intended to focused on translating genetic insights into new medicines.
23
Funding: $634M
Annexon Biosciences a biotechnology company, discovers and developing novel therapeutics for neurodegenerative and autoimmune disorders.
Annexon Biosciences a biotechnology company, discovers and developing novel therapeutics for neurodegenerative and autoimmune disorders.
24
Funding: $622.5M
Carbon Health is a developer of a mobile-based healthcare network used to offer simple, convenient, and accessible healthcare.
Carbon Health is a developer of a mobile-based healthcare network used to offer simple, convenient, and accessible healthcare.
25
Funding: $580M
Tonal uses intelligent technology, expert coaching, and personalized guidance to help any Tonal member be his or her strongest.
Tonal uses intelligent technology, expert coaching, and personalized guidance to help any Tonal member be his or her strongest.
26
Funding: $569M
Alumis is a precision medicines company that is transforming the lives of patients living with immune-mediated diseases using a precision approach to develop oral therapies.
Alumis is a precision medicines company that is transforming the lives of patients living with immune-mediated diseases using a precision approach to develop oral therapies.
27
Funding: $554M
Kardigan is a patient-driven heart health company that is modernizing cardiovascular drug development to deliver medicines that move patients beyond symptom management to functional cures.
Kardigan is a patient-driven heart health company that is modernizing cardiovascular drug development to deliver medicines that move patients beyond symptom management to functional cures.
28
Funding: $553.1M
Twist Bioscience is a synthetic DNA production for specialty chemical compounds and drug development.
Twist Bioscience is a synthetic DNA production for specialty chemical compounds and drug development.
29
Funding: $545.9M
Nurix develops small molecule inhibitors for the treatment of proliferative and degenerative diseases.
Nurix develops small molecule inhibitors for the treatment of proliferative and degenerative diseases.
30
Funding: $532.1M
One Medical is a members-only technology platform offering an array of concierge medical services. Acquired by Amazon
One Medical is a members-only technology platform offering an array of concierge medical services. Acquired by Amazon
31
Funding: $528.5M
A digital behavioral medicine company dedicated to inspiring and empowering people everywhere to live free of chronic illiness.
A digital behavioral medicine company dedicated to inspiring and empowering people everywhere to live free of chronic illiness.
32
Funding: $514M
Komodo Health created a groundbreaking predictive analytics platform that leverages real-time data to improve healthcare decision-making.
Komodo Health created a groundbreaking predictive analytics platform that leverages real-time data to improve healthcare decision-making.
33
Funding: $505.6M
Aligos Therapeutics is discovering and developing new classes of molecules that interact directly with disease-causing modalities such as viral encoded proteins and nucleic acids, as well as oncogenes and their resultant proteins in the case of their cancer indications. The company is also pursuing novel therapeutic agents aimed at activation of the patients immune system, to create lasting benefits for the diseases that cause significant morbidity and mortality.
Aligos Therapeutics is discovering and developing new classes of molecules that interact directly with disease-causing modalities such as viral encoded proteins and nucleic acids, as well as oncogenes and their resultant proteins in the case of their cancer indications. The company is also pursuing novel therapeutic agents aimed at activation of the patients immune system, to create lasting benefits for the diseases that cause significant morbidity and mortality.
34
Funding: $487M
Cerebral is a mission-driven telemedicine company that provides affordable, efficient access to treatment for anxiety, depression and insomnia.
Cerebral is a mission-driven telemedicine company that provides affordable, efficient access to treatment for anxiety, depression and insomnia.
35
Funding: $472M
PayZen is a health care fintech startup that aims to tackle the growing patient payment responsibility problem.
PayZen is a health care fintech startup that aims to tackle the growing patient payment responsibility problem.
36
Funding: $426.1M
Neurona Therapeutics develops cell therapies for neurological disorders, focusing on treatments like NRTX-1001 for epilepsy.
Neurona Therapeutics develops cell therapies for neurological disorders, focusing on treatments like NRTX-1001 for epilepsy.
37
Funding: $373M
Virta is the first clinically-proven treatment to safely and sustainably reverse type 2 diabetes without medications or surgery.
Virta is the first clinically-proven treatment to safely and sustainably reverse type 2 diabetes without medications or surgery.
38
Funding: $344M
Grand Rounds offers an employer-based technology alternative for health care services.
Grand Rounds offers an employer-based technology alternative for health care services.
39
Funding: $329.2M
ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer.
ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer.
40
Funding: $328M
Varda is a space manufacturing startup that focuses on creating products and drugs in space for terrestrial applications.
Varda is a space manufacturing startup that focuses on creating products and drugs in space for terrestrial applications.
41
Funding: $328M
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
42
Funding: $324M
Frontier Medicines is a biopharmaceutical company that develops a chemoproteomics platform to accelerate the development of medicines.
Frontier Medicines is a biopharmaceutical company that develops a chemoproteomics platform to accelerate the development of medicines.
43
Funding: $323M
Elemy is the nationwide provider of childhood mental and behavioral healthcare.
Elemy is the nationwide provider of childhood mental and behavioral healthcare.
44
Funding: $319.5M
Alector is a hypothesis-driven, neurology-focused startup that’s pioneering the discovery and development of first-in-class, immuno-modulatory therapies for Alzheimer’s disease and other neurodegenerative disorders. We are combining state-of-the-art antibody technology and recent discoveries in neuro-immunology and human genetics to develop a broad platform of novel therapeutics that harness the immune system to fight dementia and neurodegeneration.
Alector is a hypothesis-driven, neurology-focused startup that’s pioneering the discovery and development of first-in-class, immuno-modulatory therapies for Alzheimer’s disease and other neurodegenerative disorders. We are combining state-of-the-art antibody technology and recent discoveries in neuro-immunology and human genetics to develop a broad platform of novel therapeutics that harness the immune system to fight dementia and neurodegeneration.
45
Funding: $319.3M
Ambience Healthcare is the leading AI operating system for healthcare organizations.
Ambience Healthcare is the leading AI operating system for healthcare organizations.
46
Funding: $314.8M
Foodsmart provides a digital nutrition platform that uses personalized dietary recommendations to improve health outcomes.
Foodsmart provides a digital nutrition platform that uses personalized dietary recommendations to improve health outcomes.
47
Funding: $310M
Neuron23 is a developer of drugs intended to treat Parkinson's disease and Alzheimer's disease.
Neuron23 is a developer of drugs intended to treat Parkinson's disease and Alzheimer's disease.
48
Funding: $294.9M
At UNITY, we design therapeutics that prevent, halt, or reverse diseases of aging. Our medicines are designed to lengthen healthspan, the amount of time you live in good health.
At UNITY, we design therapeutics that prevent, halt, or reverse diseases of aging. Our medicines are designed to lengthen healthspan, the amount of time you live in good health.
49
Funding: $291.6M
Viz is a medical imaging company that helps optimize emergency treatment using deep learning technology.
Viz is a medical imaging company that helps optimize emergency treatment using deep learning technology.
50
Funding: $288.8M
Verana Health offers a platform for life science innovation that utilizes regulatory-grade specialty data sets.
Verana Health offers a platform for life science innovation that utilizes regulatory-grade specialty data sets.
