Top 19 Urology startups

Updated: Dec 21, 2025
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These startups develop new urological condition treatments and diagnostics technologies, like robotic-assisted surgery, multiparametric magnetic resonance imaging, endoscopic ultrasound, wearable urinary monitoring devices, artificial intelligence for diagnostic imaging, laser-based therapies
1
Tricida
Country: USA | Funding: $624M
Tricida is working to turn the tide on Metabolic Acidosis and progression of Chronic Kidney Disease. Its lead product candidate, TRC101, a non-absorbed, orally-administered polymer drug designed to treat metabolic acidosis in patients with chronic kidney disease (CKD).
2
Escient Pharmaceuticals
Country: USA | Funding: $237.5M
Escient Pharmaceuticals is a provider of bio-technical research and development services intended to focus in advancement of first-in-class G Protein-Coupled Receptor targeted drugs. The company's services focuses on offering therapies for neuro-immuno-inflammatory and autoreactive diseases
3
Allena Pharmaceuticals
Country: USA | Funding: $198.8M
Allena Pharmaceuticals is dedicated to developing and commercializing first-in-class, oral enzyme therapeutics to treat patients with rare and severe metabolic disorders that affect the kidney. The company is focused on metabolic disorders that result in excess accumulation of certain metabolites, such as oxalate and urate, that can cause kidney stones, damage the kidney, and potentially lead to chronic kidney disease, or CKD, and end-stage renal disease.
4
Healthy.io
Country: Israel | Funding: $185M
Healthy.io de Dip.io, a home-based urinalysis kit that turns a smartphone into a clinical-grade diagnostic device. It’s the first smartphone-based urine test to secure clearance as a Class 2 device.
5
Kalera Medical
Country: USA | Funding: $125.4M
Kalera Medical is the developer of a kidney stone retrieval device designed to remove kidney stone fragments. The company's device is vacuum-assisted that helps in extracting stones from a patient's kidney, enabling doctors to remove stone fragments completely, thereby addressing unmet medical needs.
6
Renalytix AI
Country: UK | Funding: $106.7M
RenalytixAI is a developer of artificial intelligence (AI) enabled clinical diagnostic solutions for kidney disease.
7
OxThera
Country: Sweden | Funding: $87.6M
OxThera is developing its Oxabact therapy that uses the O. formigenes bacteria to degrade oxalates in the intestines.
8
UroMems
Country: France | Funding: €81M
UroMems ambition is to offer to the patients suffering from severe urinary incontinence a simple and efficient innovative solution. UroMems is currently developing an active implantable medical device which compensates for sphincter insufficiency.
9
Walden Biosciences
Country: USA | Funding: $51M
Walden Biosciences develops drugs for kidney disease, taking a two-pronged approach: antibodies and small molecules.
10
SonoMotion
Country: USA | Funding: $29.1M
SonoMotion is developing non-invasive ultrasonic solutions for kidney stone disease. It allows to avoid surgical procedures by using long pulses of sound waves to push the smaller stones from the kidney safely and without anesthesia.
11
TestCard
Country: UK | Funding: $19.1M
TestCard is the innovative medtech behind the 'urine test-in-a-postcard' concept. Its accompanying mobile app provides an immediate result.
12
Avenda Health
Country: USA | Funding: $19.3M
Image guided laser therapy for prostate cancer in a doctor’s office.
13
Devicare
Country: Spain | Funding: $11.6M
Devicare has developed Lit-Control - the most advanced, comprehensive and effective medical treatment for Kidney Stones. Lit-Control is a family of four innovative medical foods that have been formulated to treat and manage the nutritional needs of patients with each of the four major groups of Kidney Stones (i.e. calcium, uric acid, infectious and cytine stones). And in combination with these medical foods, Lit-Control also incorporates a ground-breaking digital therapeutic to ease the follow-up of these patients.
14
Minze Health
Country: Belgium | Funding: $9.4M
Minze Health enables better care for billion people with Lower Urinary Tract Symptoms (LUTS).
15
Butterfly Medical
Country: USA | Funding: $9.1M
Butterfly has designed an anatomically shaped nitinol implant, which is positioned in the prostatic urethra in order to open the space and relieve BPH symptoms. The device comes in multiple sizes, and, unlike more invasive approaches, does not require any resection, cutting, or burning of prostatic tissue. The procedure can be completed in under six minutes in the urologist’s office.
16
Oxalo Therapeutics
Country: USA | Funding: $3.8M
Oxalo Therapeutics develops a first-of-its-kind peptide-based drug to prevent kidney stones.
17
DEBN
Country: Poland | Funding: $2.7M
DEBN has developed an innovative prostate biopsy needle for urologists that reduces the incidence of infectious complications by delivering an optimal combination of antibiotics directly into the prostate, precisely where infections can occur. The device consists of a polymer-coated biopsy needle and an anesthetic needle, which release the drug directly into the prostate during the procedure. The very first DEBN model used polyvinyl alcohol and amikacin.
18
NuVascular Technologies
Country: USA
NuVascular Technologies, Inc. is developing the next-generation of medical devices that will specifically treat patients suffering from end-stage renal (kidney) disease with the goal of helping patients live better and longer lives.
19
ProvenMed
Country: UAE
ProvenMed have developed the revolutionary ActivGo for men - the first urinary incontinence wearable device
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com