Top 5 Startups that help to cure Kidney Stones (Urolithiasis)

Updated: Apr 14, 2026
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Startups focused on kidney stones disease develop such technologies as extracorporeal shock wave lithotripsy, flexible ureteroscopy, laser lithotripsy, AI imaging, ultrasound lithotripsy, robotic-assisted surgery, digital health monitoring apps.
1
Calyxo
Country: USA | Funding: $125.4M
Calyxo has developed the CVAC surgical system for kidney stone removal and the corresponding procedure called SURE. The company's device utilizes irrigation and vacuum aspiration during and after laser lithotripsy to extract stones from patients' kidneys, allowing physicians to completely remove stone fragments. Independent irrigation and aspiration channels ensure continuous flow. Four angled nozzles liquefy fragments for effective removal. Dynamic aspiration removes dust during lithotripsy and removes fragments after lithotripsy. The CVAC system demonstrated safety and superior stone removal in the landmark ASPIRE study.
2
OxThera
Country: Sweden | Funding: $87.6M
OxThera is developing its Oxabact therapy that uses the O. formigenes bacteria to degrade oxalates in the intestines.
3
SonoMotion
Country: USA | Funding: $29.1M
SonoMotion is developing non-invasive ultrasonic solutions for kidney stone disease. It allows to avoid surgical procedures by using long pulses of sound waves to push the smaller stones from the kidney safely and without anesthesia.
4
Devicare
Country: Spain | Funding: $11.6M
Devicare has developed Lit-Control - the most advanced, comprehensive and effective medical treatment for Kidney Stones. Lit-Control is a family of four innovative medical foods that have been formulated to treat and manage the nutritional needs of patients with each of the four major groups of Kidney Stones (i.e. calcium, uric acid, infectious and cytine stones). And in combination with these medical foods, Lit-Control also incorporates a ground-breaking digital therapeutic to ease the follow-up of these patients.
5
Oxalo Therapeutics
Country: USA | Funding: $3.8M
Oxalo Therapeutics develops a first-of-its-kind peptide-based drug to prevent kidney stones.
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com