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Top 18 Obesity treatment startups in USA
Sep 07, 2025 | By Jason Kwon | 32 |
1
Funding: $505M
Our purpose is to reduce the physical, emotional and economic burdens of obesity as a driver of diseases, creating value for the people we serve and the investors we work for.
Our purpose is to reduce the physical, emotional and economic burdens of obesity as a driver of diseases, creating value for the people we serve and the investors we work for.
2
Funding: $1.2B
Rhythm is a biopharmaceutical company focused on developing and commercializing peptide therapeutics
Rhythm is a biopharmaceutical company focused on developing and commercializing peptide therapeutics
3
Funding: $400M
Kailera Therapeutics is a clinical-stage biotechnology company developing anti-obesity drugs.
Kailera Therapeutics is a clinical-stage biotechnology company developing anti-obesity drugs.
4
Funding: $301M
Viome has developed technology aimed at balancing microorganisms in the gut. With Viome, you can fine-tune the function of your gut microbiome with a personalized diet to minimize the production of harmful metabolites and maximize the production of beneficial ones, so that you experience increased energy and general well-being, all while reaching and maintaining a healthy state of balance.
Viome has developed technology aimed at balancing microorganisms in the gut. With Viome, you can fine-tune the function of your gut microbiome with a personalized diet to minimize the production of harmful metabolites and maximize the production of beneficial ones, so that you experience increased energy and general well-being, all while reaching and maintaining a healthy state of balance.
5
Funding: $293.9M
BioAge Labs is a clinical-stage biotechnology company that develops therapeutics to treat obesity and metabolic diseases.
BioAge Labs is a clinical-stage biotechnology company that develops therapeutics to treat obesity and metabolic diseases.
6
Funding: $290M
Rivus Pharmaceuticals is dedicated to improving metabolic health by developing controlled metabolic accelerators (CMAs) that treat metabolic disorders, including the tricky nonalcoholic steatohepatitis (NASH), cardio-metabolic diseases and obesity, via weight loss.
Rivus Pharmaceuticals is dedicated to improving metabolic health by developing controlled metabolic accelerators (CMAs) that treat metabolic disorders, including the tricky nonalcoholic steatohepatitis (NASH), cardio-metabolic diseases and obesity, via weight loss.
7
Funding: $220.9M
Allurion Technologies develops a medical device for weight loss that can be delivered and removed without surgery or endoscopy.
Allurion Technologies develops a medical device for weight loss that can be delivered and removed without surgery or endoscopy.
8
Funding: $194.4M
ReShape Lifesciences is a developer of minimally invasive medical devices to treat obesity and metabolic diseases.
ReShape Lifesciences is a developer of minimally invasive medical devices to treat obesity and metabolic diseases.
9
Funding: $127.6M
Calibrate is a digital metabolic health business that provides a virtual program for weight loss.
Calibrate is a digital metabolic health business that provides a virtual program for weight loss.
10
Funding: $81.5M
USGI Medical develops technologies to enable incisionless surgeries that treat diseases through the natural passageways of the body. The goal is to reduce the size of the stomach using proprietary tissue anchors using a noninvasive, endoscopic procedure requiring no incisions.
USGI Medical develops technologies to enable incisionless surgeries that treat diseases through the natural passageways of the body. The goal is to reduce the size of the stomach using proprietary tissue anchors using a noninvasive, endoscopic procedure requiring no incisions.
11
Funding: $65M
Helicore Biopharma is a biopharmaceutical company that discovers and develops novel weight-loss therapeutics.
Helicore Biopharma is a biopharmaceutical company that discovers and develops novel weight-loss therapeutics.
12
Funding: $64.3M
Form Health is a telemedical weight loss company that focuses on individuals dealing with obesity.
Form Health is a telemedical weight loss company that focuses on individuals dealing with obesity.
13
Funding: $30M
Cloud Health Systems provides consultations and other health services to consumers, first focusing on metabolic health and obesity.
Cloud Health Systems provides consultations and other health services to consumers, first focusing on metabolic health and obesity.
14
Funding: $11M
Phenomix Sciences an early-stage spinout of the Mayo Clinic focused on personalized treatments for chronic diseases. Its first product tackles obesity with a novel blood-based test that is designed to accurately predict the subtype of obesity with a sensitivity and specificity >90%.
Phenomix Sciences an early-stage spinout of the Mayo Clinic focused on personalized treatments for chronic diseases. Its first product tackles obesity with a novel blood-based test that is designed to accurately predict the subtype of obesity with a sensitivity and specificity >90%.
16
Funding: $3.3M
Adipo Therapeutics is developing polymer-based, Notch-inhibiting nanoparticles that are injected directly into adipose (fat) tissue to induce browning, or white-to-beige adipocyte transformation.
Adipo Therapeutics is developing polymer-based, Notch-inhibiting nanoparticles that are injected directly into adipose (fat) tissue to induce browning, or white-to-beige adipocyte transformation.
17
Funding: $3.2M
MelliCell develops therapeutics for diabetes and obesity using a proprietary in vitro model of weight gain in human fat cells.
MelliCell develops therapeutics for diabetes and obesity using a proprietary in vitro model of weight gain in human fat cells.
18
Phyteau is developing completely safe and effective therapeutics to give people control over their metabolism, blood sugar and weight. Our approach represents a new class of incretin-based therapy for diabetes, obesity and related metabolic conditions like NASH, NAFLD and prediabetes.
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