Top 25 Gastroenterology startups

Updated: Mar 19, 2026
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Gastroenterology startups are developing solutions such as AI-powered diagnostic algorithms, capsule endoscopy, smart pills for targeted drug delivery, virtual colonoscopy, fecal microbiota transplantation, robotic-assisted surgery, etc.
1
Ventyx Biosciences
Country: USA | Funding: $468.6M
Ventyx Biosciences develops a drug for inflammatory bowel disease
2
Salvo Health
Country: USA | Funding: $22M
Salvo Health offers a virtual clinic geared toward people with chronic gut problems, including irritable bowel syndrome (IBS), celiac disease, gastroesophageal reflux disease (GERD), dyspepsia and small intestinal bacterial overgrowth (SIBO).
3
Rhythm Pharmaceuticals
Country: USA | Funding: $1.2B
Rhythm is a biopharmaceutical company focused on developing and commercializing peptide therapeutics
4
Seres Therapeutics
Country: USA | Funding: $537.8M
Seres Therapeutics is creating a new class of medicines to treat diseases resulting from functional deficiencies in the microbiome, a condition known as dysbiosis
5
Synergy Pharmaceuticals
Country: USA | Funding: $407.2M
Synergy is a gastrointestinal-focused biopharmaceutical company committed to science-based innovation, providing novel treatment options for patients and healthcare providers, rewarding opportunities for our employees, and creating exceptional value for our shareholders.
6
Allurion Technologies
Country: USA | Funding: $225.9M
Allurion Technologies develops a medical device for weight loss that can be delivered and removed without surgery or endoscopy.
7
Oshi Health
Country: USA | Funding: $119.5M
Oshi Health is a virtual-first medical practice revolutionizing the diagnosis, management and treatment of digestive health conditions.
8
CapsoVision
Country: USA | Funding: $105.6M
CapsoVision is a medical device company developing gastrointestinal medical devices.
9
Vivante Health
Country: USA | Funding: $58.8M
Vivante makes a digital program for digestive health and disease called GIThrive that includes, among other tools, a 24-7 support line to a gastrointestinal care team.
10
Enthera
Country: Italy | Funding: €39M
Enthera's mission is to find new therapeutic approaches to treat diabetes and related gastrointestinal complication (enteropathy), as well as other intestinal disorders sharing the same biological pathway.
11
Alimetry
Country: New Zealand | Funding: $34.9M
Alimetry develops Gastric Alimetry system is medical device which performs Body Surface Gastric Mapping. It is intended to record, store, view and process gastric electrophysiology as an aid in the diagnosis of various gastric disorders.
12
Nerv Technology
Country: Canada | Funding: $35.4M
Medical Device startup developing a solution to detect gastrointestinal leaks after surgical procedures.
13
ENvizion Medical
Country: Israel | Funding: $19M
Envizion Medical develops electromagnetic feeding tube placement devices.
14
Cara Care
Country: Germany | Funding: $16M
Cara Care empowers patients suffering from chronic digestive diseases to live a healthier and happier life.
15
Vibrant Gastro
Country: Israel | Funding: $15M
Vibrant has developed the first non-drug treatment for chronic constipation via mechanical stimulation of the gut, that helps patients obtain relief and live better with their condition. The treatment empowers physicians with digital tools to provide optimized and better care.
16
Vibrant
Country: Israel | Funding: $15M
Vibrant is a developer and producer of chemical-free capsule for constipation treatment.
17
AMILI
Country: Singapore | Funding: $10.5M
Asian Microbiome Library microbiome company and a stool bank serving as a hub for gut microbiome therapy.
18
Endogene
Country: Australia | Funding: $10M
Endogene has developed a self-advancing single-use gastrointestinal endoscope platform. Provides safe, timely, relaible and cost-effective access to entire GI tract. Advanced 4k imaging and AI-assisted diagnose.
19
TargEDys
Country: France | Funding: $10.3M
SAS TargEDys develops mechanisms involving hormone mimetic proteins linked to microbiota for the treatment of eating disorders such as hyperphagia or anorexia.
20
metaMe Health
Country: USA | Funding: $6.4M
MetaMe Health is committed to developing FDA-approved prescription digital therapeutics for the treatment of gastrointestinal conditions.
21
EnteraSense
Country: Ireland | Funding: €3.5M
EnteraSense is developing an ingestible biosensor that detects bleeding in the gastrointestinal tract in real time without requiring a complicated intervention.
22
Exosomm
Country: Israel | Funding: $3.9M
Exosomm develops food solutions based on natural milk exosomes. Exosomm’s first product is a food formula with a patented-based active anti-inflammatory effect designed for patients with inflammatory bowel diseases (Crohn´s & Colitis).
23
SmartTab
Country: USA | Funding: $2.2M
SmartTab is a digital medicine company which develops innovative wireless drug delivery and monitoring systems.
24
Kiwi Bio
Country: USA | Funding: $1.6M
Kiwi Bio aims to free irritable bowel syndrome sufferers from restrictive diets. Kiwi’s product FODZYME uses patent-pending enzymes to break down common digestive triggers.
25
Casa de Sante
Country: USA
Casa de Sante is transforming gut health through convenient, personalized and virtual therapeutic care.
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com