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Top 18 Chronic back pain treatment startups
Oct 28, 2025 | By Jason Kwon | 18 |
These startups develop new technologies to address chronic back pain: minimally invasive spine surgery, spinal cord stimulation, radiofrequency ablation, regenerative medicine (like platelet-rich plasma therapy), wearable pain management devices, artificial intelligence for pain assessment.
1
Country: USA | Funding: $1B
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
2
Country: USA | Funding: $411.3M
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
3
Country: USA | Funding: $188.8M
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
4
Country: USA | Funding: $150M
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
5
Country: USA | Funding: $134.2M
SiteOne Therapeutics is a biopharmaceutical company that develops pain therapeutics to treat sensory hyperexcitability disorders.
SiteOne Therapeutics is a biopharmaceutical company that develops pain therapeutics to treat sensory hyperexcitability disorders.
6
Country: Germany | Funding: $125M
kaia is a digital therapeutics company focused on AI-powered management of chronic pain
kaia is a digital therapeutics company focused on AI-powered management of chronic pain
7
Country: USA | Funding: $71M
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
8
Country: USA | Funding: $28.4M
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
9
Country: USA | Funding: $27M
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
10
Country: France | Funding: $24.8M
Remedee is the next generation pain relief offering a new and individualized therapy to every patient.
Remedee is the next generation pain relief offering a new and individualized therapy to every patient.
11
Country: Australia | Funding: $19.7M
Mindset Health helps improve recurring health issues like irritable bowel syndrome and anxiety with app-based hypnotherapy.
Mindset Health helps improve recurring health issues like irritable bowel syndrome and anxiety with app-based hypnotherapy.
12
Country: USA | Funding: $20M
Clearing is a healthcare platform focused on providing opioid-free pain relief.
Clearing is a healthcare platform focused on providing opioid-free pain relief.
13
Country: USA | Funding: $19M
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
14
Country: India | Funding: $2.5M
FlexifyMe is a health tech platform for chronic musculoskeletal pain management
FlexifyMe is a health tech platform for chronic musculoskeletal pain management
15
Country: Israel | Funding: $2.2M
Healables delivers drug-free pain relief solutions through the convergence of biotechnology, digital health, IoT & wearable technologies. Healables makes a wearable therapeutic device that treats the source of the pain by accelerating the healing of cells and tissues.
Healables delivers drug-free pain relief solutions through the convergence of biotechnology, digital health, IoT & wearable technologies. Healables makes a wearable therapeutic device that treats the source of the pain by accelerating the healing of cells and tissues.
16
Country: Netherlands | Funding: $1M
Reducept fights chronic pain with Virtual Reality. They have succeeded in developing a program that trains your brain to handle pain.
Reducept fights chronic pain with Virtual Reality. They have succeeded in developing a program that trains your brain to handle pain.
17
Country: Netherlands
AudioFysio focuses on audio exercise programs that are developed for back pain and back exercise.
AudioFysio focuses on audio exercise programs that are developed for back pain and back exercise.
18
Country: USA
NeuroTechnology develops CORDUS appliance that helps to treat effectively back pain
NeuroTechnology develops CORDUS appliance that helps to treat effectively back pain
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