Top 17 Chronic back pain treatment startups

Updated: Dec 21, 2025
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These startups develop new technologies to address chronic back pain: minimally invasive spine surgery, spinal cord stimulation, radiofrequency ablation, regenerative medicine (like platelet-rich plasma therapy), wearable pain management devices, artificial intelligence for pain assessment.
1
Hinge Health
Country: USA | Funding: $1B
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
2
Eliem Therapeutics
Country: USA | Funding: $411.3M
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
3
Latigo Biotherapeutics
Country: USA | Funding: $300M
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
4
SPR Therapeutics
Country: USA | Funding: $188.8M
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
5
Kaia Health
Country: Germany | Funding: $125M
kaia is a digital therapeutics company focused on AI-powered management of chronic pain
6
AppliedVR
Country: USA | Funding: $71M
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
7
Wavegate
Country: USA | Funding: $31.2M
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
8
SpineZone
Country: USA | Funding: $27M
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
9
Remedee Labs
Country: France | Funding: $24.8M
Remedee is the next generation pain relief offering a new and individualized therapy to every patient.
10
Clearing
Country: USA | Funding: $20M
Clearing is a healthcare platform focused on providing opioid-free pain relief.
11
Mindset Health
Country: Australia | Funding: $19.7M
Mindset Health helps improve recurring health issues like irritable bowel syndrome and anxiety with app-based hypnotherapy.
12
Artelo Biosciences
Country: USA | Funding: $19M
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
13
FlexifyMe
Country: India | Funding: $2.5M
FlexifyMe is a health tech platform for chronic musculoskeletal pain management
14
Healables
Country: Israel | Funding: $2.2M
Healables delivers drug-free pain relief solutions through the convergence of biotechnology, digital health, IoT & wearable technologies. Healables makes a wearable therapeutic device that treats the source of the pain by accelerating the healing of cells and tissues.
15
Reducept
Country: Netherlands | Funding: $1M
Reducept fights chronic pain with Virtual Reality. They have succeeded in developing a program that trains your brain to handle pain.
16
AudioFysio
Country: Netherlands
AudioFysio focuses on audio exercise programs that are developed for back pain and back exercise.
17
NeuroTechnology
Country: USA
NeuroTechnology develops CORDUS appliance that helps to treat effectively back pain
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com