Top 13 Chronic Pain Treatment startups in USA
May 03, 2026
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18
1
Funding: $65.5M
Nervonik is a medical device company developing an opioid-free peripheral nerve stimulation (PNS) system.
Nervonik is a medical device company developing an opioid-free peripheral nerve stimulation (PNS) system.
2
Funding: $125M
Ambros was created to test and market neridronate, a drug designed to reduce pain in complex regional pain syndrome type 1, in North America. The startup acquired the rights to this drug from the Italian company Abiogen (the drug is approved in Italy). CRPS-1, formerly known as reflex sympathetic dystrophy, is a rare disorder characterized by intense and sometimes continuous pain in the affected limb following a bone injury.
Ambros was created to test and market neridronate, a drug designed to reduce pain in complex regional pain syndrome type 1, in North America. The startup acquired the rights to this drug from the Italian company Abiogen (the drug is approved in Italy). CRPS-1, formerly known as reflex sympathetic dystrophy, is a rare disorder characterized by intense and sometimes continuous pain in the affected limb following a bone injury.
3
Funding: $16.2M
Lin is an online pain management platform offering personalized, evidence-based programs from experts. It matches patients with chronic pain with personalized pain recovery consultant to create a customized treatment plan. The consultant guides them throughout the program and multidisciplinary clinical team provides oversight. Although the platform uses artificial intelligence to scale, all care is provided by humans. Treatments are not medication-based, but rather brain-focused techniques and physical therapy. The company partners with healthcare providers and insurance companies to offer patients evidence-based, low-risk chronic pain treatments.
Lin is an online pain management platform offering personalized, evidence-based programs from experts. It matches patients with chronic pain with personalized pain recovery consultant to create a customized treatment plan. The consultant guides them throughout the program and multidisciplinary clinical team provides oversight. Although the platform uses artificial intelligence to scale, all care is provided by humans. Treatments are not medication-based, but rather brain-focused techniques and physical therapy. The company partners with healthcare providers and insurance companies to offer patients evidence-based, low-risk chronic pain treatments.
4
Funding: $1B
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
5
Funding: $411.3M
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
6
Funding: $300M
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
7
Funding: $188.8M
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
8
Funding: $71M
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
9
Funding: $31.2M
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
10
Funding: $27M
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
11
Funding: $20M
Clearing is a healthcare platform focused on providing opioid-free pain relief.
Clearing is a healthcare platform focused on providing opioid-free pain relief.
12
Funding: $19M
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
13
NeuroTechnology develops CORDUS appliance that helps to treat effectively back pain
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