Top 6 Startups developing new antibiotics

Updated: May 22, 2026
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These startups use next-generation sequencing, machine learning algorithms, and synthetic biology approaches to combat antibiotic resistance and discover new antibiotics
1
Spero Therapeutics
Country: USA | Funding: $443.6M
Spero Therapeutics develops medications for patients suffering from rare diseases and multidrug-resistant bacterial infections. Its lead drug, the antibiotic Tebipenem HBr, is an oral carbapenem being developed for the treatment of complicated urinary tract infections, including pyelonephritis. If approved, Tebipenem, which has already successfully completed Phase 3 clinical trials, will be the first oral carbapenem for the treatment of this disease. Carbapenems are an important subclass of antibiotics for the treatment of infections caused by drug-resistant Gram-negative bacteria. Carbapenems have become the standard of care for many infections caused by multidrug-resistant Gram-negative bacteria, but are currently only available as intravenous formulations for this indication.
2
Micreos
Country: Netherlands | Funding: €96.1M
Micreos is a developer of phage technology for targeted control of bacteria. Micreos’ big idea is to use enzymes made by bacteriophages to selectively take out bacteria without drug resistance.
3
Botanix Pharmaceuticals
Country: Australia | Funding: $82.6M
Botanix Pharmaceuticals intends to improve the lives of patients suffering from serious skin diseases including acne, psoriasis and atopic dermatitis using a novel therapeutic and advanced transdermal drug delivery system.
4
Aridis Pharmaceuticals
Country: USA | Funding: $81.7M
Aridis is a biopharmaceutical company focused on the development of human antibodies for hospital-related infections
5
NovoBiotic Pharmaceuticals
Country: USA | Funding: $147.3K
NovoBiotic Pharmaceuticals is a biotechnology company focused on the discovery and development of new drugs from natural sources.
6
Pattern BioSciences
Country: Switzerland | Funding: €71.4K
Pattern’s Digital Culture technology will deliver pathogen identification (ID) and antibiotic susceptibility test (AST) results together within four hours.
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com