1
Country: USA | Funding: $1.1B
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
2
Country: USA | Funding: $614.6M
Neumora Therapeutics develops precision therapies for treatment of brain diseases. Its uses the propriety platform Precision Toolbox, which includes a suite of translational, medical and computational tools for information discovery, capable of applying precision medicine approaches. Its therapeutic portfolio includes seven programs for the treatment of neuropsychiatric disorders and neurodegenerative diseases (major depressive disorder, Alzheimer's disease, schizophrenia, and Parkinson's disease). Neumora's lead program, navacaprant, is a novel, highly selective kappa opioid receptor (KOR) antagonist nearing the end of development as a reliable monotherapy for the treatment of MDD. Navacaprant is an investigational, once-daily oral medication designed to modulate dopamine and reward signaling pathways, which play a critical role in the regulation of mood, cognition, reward and behavior.
Neumora Therapeutics develops precision therapies for treatment of brain diseases. Its uses the propriety platform Precision Toolbox, which includes a suite of translational, medical and computational tools for information discovery, capable of applying precision medicine approaches. Its therapeutic portfolio includes seven programs for the treatment of neuropsychiatric disorders and neurodegenerative diseases (major depressive disorder, Alzheimer's disease, schizophrenia, and Parkinson's disease). Neumora's lead program, navacaprant, is a novel, highly selective kappa opioid receptor (KOR) antagonist nearing the end of development as a reliable monotherapy for the treatment of MDD. Navacaprant is an investigational, once-daily oral medication designed to modulate dopamine and reward signaling pathways, which play a critical role in the regulation of mood, cognition, reward and behavior.
3
Country: USA | Funding: $448.5M
Amylyx Pharmaceutical is a pharmaceutical company that specializes in providing solutions on Alzheimer’s and other diseases of the brain.
Amylyx Pharmaceutical is a pharmaceutical company that specializes in providing solutions on Alzheimer’s and other diseases of the brain.
4
Country: USA | Funding: $374M
Voyager Therapeutics is a clinical stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system (CNS). Gene therapy has the potential to transform the treatment of CNS and other diseases by providing a one-time therapy that dramatically improves patients' lives.
Voyager Therapeutics is a clinical stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system (CNS). Gene therapy has the potential to transform the treatment of CNS and other diseases by providing a one-time therapy that dramatically improves patients' lives.
5
Country: USA | Funding: $366.2M
Alzheon is committed to developing innovative medicines for patients suffering from Alzheimer's disease and other neurological and psychiatric disorders. Our Alzheon’s drug development platform which comprises proprietary chemistries, robust clinical efficacy and safety datasets in patients and genetically-defined subpopulations, and the ability to optimize molecules to have the desired therapeutic attributes.
Alzheon is committed to developing innovative medicines for patients suffering from Alzheimer's disease and other neurological and psychiatric disorders. Our Alzheon’s drug development platform which comprises proprietary chemistries, robust clinical efficacy and safety datasets in patients and genetically-defined subpopulations, and the ability to optimize molecules to have the desired therapeutic attributes.
6
Country: USA | Funding: $360M
LEXEO Therapeutics develops gene therapy for the world's most devastating diseases
LEXEO Therapeutics develops gene therapy for the world's most devastating diseases
7
Country: USA | Funding: $319.5M
Alector is a hypothesis-driven, neurology-focused startup that’s pioneering the discovery and development of first-in-class, immuno-modulatory therapies for Alzheimer’s disease and other neurodegenerative disorders. We are combining state-of-the-art antibody technology and recent discoveries in neuro-immunology and human genetics to develop a broad platform of novel therapeutics that harness the immune system to fight dementia and neurodegeneration.
Alector is a hypothesis-driven, neurology-focused startup that’s pioneering the discovery and development of first-in-class, immuno-modulatory therapies for Alzheimer’s disease and other neurodegenerative disorders. We are combining state-of-the-art antibody technology and recent discoveries in neuro-immunology and human genetics to develop a broad platform of novel therapeutics that harness the immune system to fight dementia and neurodegeneration.
8
Country: USA | Funding: $295.1M
Acumen Pharmaceuticals is focused on discovering and developing best in class therapeutics and diagnostics for Alzheimer’s disease.
Acumen Pharmaceuticals is focused on discovering and developing best in class therapeutics and diagnostics for Alzheimer’s disease.
9
Country: USA | Funding: $257.4M
Codiak Biosciences is developing multiple platforms for both therapeutic and diagnostic applications based on a growing appreciation for exosome biology.
Codiak Biosciences is developing multiple platforms for both therapeutic and diagnostic applications based on a growing appreciation for exosome biology.
10
Country: USA | Funding: $247M
Quince Therapeutics is developing novel treatments for altering the course of Alzheimer's and other degenerative diseases.
Quince Therapeutics is developing novel treatments for altering the course of Alzheimer's and other degenerative diseases.
11
Country: USA | Funding: $186M
BioXcel Therapeutics is a clinical stage biopharmaceutical company that utilizes novel artificial intelligence, or AI, to identify the next wave of medicines across neuroscience and immuno-oncology.
BioXcel Therapeutics is a clinical stage biopharmaceutical company that utilizes novel artificial intelligence, or AI, to identify the next wave of medicines across neuroscience and immuno-oncology.
12
Country: USA | Funding: $180M
Vigil Neuroscience is a biotechnology company that develops novel therapeutics for neurodegenerative diseases.
Vigil Neuroscience is a biotechnology company that develops novel therapeutics for neurodegenerative diseases.
13
Country: Netherlands | Funding: €160M
VectorY Therapeutics develops gene therapies against amyotrophic lateral sclerosis (ALS) and Alzhiemer’s disease.
VectorY Therapeutics develops gene therapies against amyotrophic lateral sclerosis (ALS) and Alzhiemer’s disease.
14
Country: South Korea | Funding: $137M
D&D Pharmatech is a biotech company that funds the development of revolutionary medicines through disease-specific subsidiary companies founded and guided by top-tier medical research faculty. This corporate structure creates a unique opportunity to accelerate translation of cutting-edge research into lifesaving therapeutic products for patients. The company’s product pipeline focuses on a range of indications including neurodegenerative and fibrotic diseases.
D&D Pharmatech is a biotech company that funds the development of revolutionary medicines through disease-specific subsidiary companies founded and guided by top-tier medical research faculty. This corporate structure creates a unique opportunity to accelerate translation of cutting-edge research into lifesaving therapeutic products for patients. The company’s product pipeline focuses on a range of indications including neurodegenerative and fibrotic diseases.
15
Country: USA | Funding: $134.1M
We use genomic data to find better drugs, faster. We find new cures for brain diseases 1000X more cheaply and quickly using our proven network algorithms.
We use genomic data to find better drugs, faster. We find new cures for brain diseases 1000X more cheaply and quickly using our proven network algorithms.
16
Country: USA | Funding: $86.9M
Vaccinex develops novel therapeutic antibodies for treatment of neurodegenerative diseases and cancer. Its drugs are based on the inhibition of semaphorin SEMA4D - potent biological effector believed to prevent immune infiltration and induce myeloid-derived suppressor cells in tumors, as well as trigger neuroinflammation through reactive gliosis in the brain. The company's lead drug candidate, pepinemab, blocks SEMA4D and has the potential to enhance immune activity against tumors and reprogram underlying pathogenic immune mechanisms that exacerbate damage in chronic neurological diseases such as Asheimer's disease and Huntington's disease. The company is also advancing candidates for the treatment of cervical, pancreatic and lung cancer. Vaccinex uses its proprietary ActivMAb drug discovery platform, which enables the discovery and development of highly selective antibodies with novel mechanisms of action against complex membrane proteins.
Vaccinex develops novel therapeutic antibodies for treatment of neurodegenerative diseases and cancer. Its drugs are based on the inhibition of semaphorin SEMA4D - potent biological effector believed to prevent immune infiltration and induce myeloid-derived suppressor cells in tumors, as well as trigger neuroinflammation through reactive gliosis in the brain. The company's lead drug candidate, pepinemab, blocks SEMA4D and has the potential to enhance immune activity against tumors and reprogram underlying pathogenic immune mechanisms that exacerbate damage in chronic neurological diseases such as Asheimer's disease and Huntington's disease. The company is also advancing candidates for the treatment of cervical, pancreatic and lung cancer. Vaccinex uses its proprietary ActivMAb drug discovery platform, which enables the discovery and development of highly selective antibodies with novel mechanisms of action against complex membrane proteins.
17
Country: Denmark | Funding: $77.9M
Muna develops transformative therapeutics to preserve brain function and enhance resilience to neurodegenerative diseases
Muna develops transformative therapeutics to preserve brain function and enhance resilience to neurodegenerative diseases
18
Country: USA | Funding: $60.4M
Neurotrack is a digital health company dedicated to the development of non-invasive cognitive health assessment tools that will enable earlier and more effective evaluation of patients who may be at risk for cognitive decline, and help advance research of treatments for cognitive diseases, including Alzheimer's. We are driven by the belief that cognitive decline and conditions like Alzheimer’s disease can be beaten if detected early. Our energy and passion goes into developing digital tools to facilitate groundbreaking change.
Neurotrack is a digital health company dedicated to the development of non-invasive cognitive health assessment tools that will enable earlier and more effective evaluation of patients who may be at risk for cognitive decline, and help advance research of treatments for cognitive diseases, including Alzheimer's. We are driven by the belief that cognitive decline and conditions like Alzheimer’s disease can be beaten if detected early. Our energy and passion goes into developing digital tools to facilitate groundbreaking change.
19
Country: USA | Funding: $40.3M
T3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders.
T3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders.
20
Country: UK | Funding: $40.3M
WaveBreak Therapeutics is a biopharmaceutical company based, focused on drug discovery and development for protein misfolding diseases.
WaveBreak Therapeutics is a biopharmaceutical company based, focused on drug discovery and development for protein misfolding diseases.
21
Country: South Korea | Funding: ₩48B
NEUROPHET is a medical SW company using advanced neuroscience and AI technologies for better brain treatment. In particular it develops Alzheimer's disease diagnosis platform.
NEUROPHET is a medical SW company using advanced neuroscience and AI technologies for better brain treatment. In particular it develops Alzheimer's disease diagnosis platform.
22
Country: Belgium | Funding: €29.7M
Amyl Therapeutics unique technology offers a curative solution for all forms of amyloid mediated diseases
Amyl Therapeutics unique technology offers a curative solution for all forms of amyloid mediated diseases
23
Country: USA | Funding: $24.7M
Altoida Medical Device (AMD) provides health care professionals objective measurements of cognitive performance.
Altoida Medical Device (AMD) provides health care professionals objective measurements of cognitive performance.
24
Country: Canada | Funding: $25.2M
Optina Diagnostics develops technology for the early detection of disease through the eye.
Optina Diagnostics develops technology for the early detection of disease through the eye.
25
Country: USA | Funding: $21.2M
NeuroVision is developing a noninvasive, quick, and inexpensive retinal imaging test for the early detection and diagnosis of Alzheimer’s disease. Our proprietary technology allows us to image amyloid beta plaque (the hallmark sign of the disease) in the retina.
NeuroVision is developing a noninvasive, quick, and inexpensive retinal imaging test for the early detection and diagnosis of Alzheimer’s disease. Our proprietary technology allows us to image amyloid beta plaque (the hallmark sign of the disease) in the retina.
26
Country: Spain
Araclon Biotech is a company dedicated to the research and development of therapies and diagnostic methods to be applied to degenerative diseases, currently focusing on Alzheimer’s disease.
Araclon Biotech is a company dedicated to the research and development of therapies and diagnostic methods to be applied to degenerative diseases, currently focusing on Alzheimer’s disease.
27
Country: USA | Funding: $14.4M
AgeneBio is developing innovative therapeutics for unserved patients afflicted with neurological and psychiatric diseases to preserve and restore brain function.
AgeneBio is developing innovative therapeutics for unserved patients afflicted with neurological and psychiatric diseases to preserve and restore brain function.
28
Country: South Korea | Funding: $13.4M
Through use of technology in which measures and modulates brain signals, we develop research protocols that improve cognitive functions. We provide meaningful information retrieved from the wearable devices through analysis of brain signal big data. With this big data, we predict and diagnose the stages of the neurological diseases such as Alzheimer’s disease and mild cognitive impairment.
Through use of technology in which measures and modulates brain signals, we develop research protocols that improve cognitive functions. We provide meaningful information retrieved from the wearable devices through analysis of brain signal big data. With this big data, we predict and diagnose the stages of the neurological diseases such as Alzheimer’s disease and mild cognitive impairment.
29
Country: Canada | Funding: $10.7M
RetiSpec is a medical imaging startup developing an eye scanner for early detection of Alzheimer’s Disease pathology.
RetiSpec is a medical imaging startup developing an eye scanner for early detection of Alzheimer’s Disease pathology.
30
Country: USA | Funding: $10M
Telocyte focuses on the development of telomerase therapy to treat Alzheimer's disease.
Telocyte focuses on the development of telomerase therapy to treat Alzheimer's disease.
31
Country: Canada | Funding: CA$14M
Grey Matter Neurosciences develops new medical devices and drug-device combinations to treat age-related brain illnesses.
Grey Matter Neurosciences develops new medical devices and drug-device combinations to treat age-related brain illnesses.
32
Country: UK | Funding: $120K
We use Machine learning to automatically derive accurate brain features (e.g. the volume of the hippocampus) from brain scans and compare them to a normative population. We also provide handy 2D and 3D visualisations of brain features. This not only saves time to neuroradiologists but also empowers them to make highly accurate reports, by using the latest techniques and findings in neurosciences
We use Machine learning to automatically derive accurate brain features (e.g. the volume of the hippocampus) from brain scans and compare them to a normative population. We also provide handy 2D and 3D visualisations of brain features. This not only saves time to neuroradiologists but also empowers them to make highly accurate reports, by using the latest techniques and findings in neurosciences
33
Country: UK
Perdeca offers two digital health products. One helps anyone to make better decisions. The other assists families and carers of patients living with dementia including Alzheimer’s to join them in memory re-connection sessions.
Perdeca offers two digital health products. One helps anyone to make better decisions. The other assists families and carers of patients living with dementia including Alzheimer’s to join them in memory re-connection sessions.
34
Country: USA
Preclinical stage MedTech company developing an early diagnostic and a device to prevent Alzheimer's disease
Preclinical stage MedTech company developing an early diagnostic and a device to prevent Alzheimer's disease
35
Country: Germany
Priavoid envisions curing neurological disorders by developing innovative treatment strategies based on a new class of orally available compounds. Focusing on indications with significant unmet medical need Priavoid applies the therapeutic concept to Alzheimer’s disease (AD), neuropathic pain and other neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), tauopathies, Parkinson’s disease (PD), and Huntington’s disease (HD).
Priavoid envisions curing neurological disorders by developing innovative treatment strategies based on a new class of orally available compounds. Focusing on indications with significant unmet medical need Priavoid applies the therapeutic concept to Alzheimer’s disease (AD), neuropathic pain and other neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), tauopathies, Parkinson’s disease (PD), and Huntington’s disease (HD).
36
Country: USA
Iluminos Therapeutics creates compounds that have the potential to treat neurodegenerative disease, in particular Alzheimer’s disease.
Iluminos Therapeutics creates compounds that have the potential to treat neurodegenerative disease, in particular Alzheimer’s disease.
