Top 50 Healthcare optimization startups in USA
May 18, 2026
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21
1
Funding: $163M
AcuityMD is a targeting platform for medical device companies that automatically uncovers new opportunities and keeps track of existing users across each of the products you sell. Stop the manual research and data entry and start connecting with your future users.
AcuityMD is a targeting platform for medical device companies that automatically uncovers new opportunities and keeps track of existing users across each of the products you sell. Stop the manual research and data entry and start connecting with your future users.
2
Funding: $95.3M
Turquoise Health is a health tech company that simplifies administration to reduce the expense and complexity of healthcare.
Turquoise Health is a health tech company that simplifies administration to reduce the expense and complexity of healthcare.
3
Funding: $2M
SpendRule, a contract intelligence platform, makes contracts the first line of defense against overpayments.
SpendRule, a contract intelligence platform, makes contracts the first line of defense against overpayments.
4
Funding: $219.3M
Garner Health is a provider of healthcare services used to help employers give their employees a better healthcare experience.
Garner Health is a provider of healthcare services used to help employers give their employees a better healthcare experience.
5
Funding: $204M
Solace Health creates healthcare navigation platform that connects patients with experienced expert advocates via phone, text or email. The experts help navigate the care process, whether it's receiving a new diagnosis, finding a doctor, coordinating treatment, obtaining authorizations or managing a chronic condition. The service is covered by Medicare, most Medicare Advantage plans and some insurance companies. The company partners with healthcare providers and offers its own electronic health record card for updates and expert's access to patient medical records to assist with the navigation process.
Solace Health creates healthcare navigation platform that connects patients with experienced expert advocates via phone, text or email. The experts help navigate the care process, whether it's receiving a new diagnosis, finding a doctor, coordinating treatment, obtaining authorizations or managing a chronic condition. The service is covered by Medicare, most Medicare Advantage plans and some insurance companies. The company partners with healthcare providers and offers its own electronic health record card for updates and expert's access to patient medical records to assist with the navigation process.
6
Funding: $204M
Solace is a digital health platform that connects patients with professional health advocates.
Solace is a digital health platform that connects patients with professional health advocates.
7
Funding: $2B
Oscar is a health insurance company that employs technology, design, and data to humanize health care.
Oscar is a health insurance company that employs technology, design, and data to humanize health care.
9
Funding: $719M
Collective Health is creating the health insurance experience we all want and deserve. We’re starting by fixing what’s broken for US employers, who bear the brunt of most of our country’s private healthcare costs.
Collective Health is creating the health insurance experience we all want and deserve. We’re starting by fixing what’s broken for US employers, who bear the brunt of most of our country’s private healthcare costs.
10
Funding: $677.9M
Aledade is a primary care physician platform that provides everything doctors need to create and run an accountable care organization.
Aledade is a primary care physician platform that provides everything doctors need to create and run an accountable care organization.
11
Funding: $497M
Color provides a high-quality, physician-ordered, genetic test at a low cost. We include support for physicians, as well as genetic counseling as part of every purchase. Our goal is to expand physician-supported access to genetic testing for hereditary cancer risk to every person, everywhere.
Color provides a high-quality, physician-ordered, genetic test at a low cost. We include support for physicians, as well as genetic counseling as part of every purchase. Our goal is to expand physician-supported access to genetic testing for hereditary cancer risk to every person, everywhere.
12
Funding: $458.7M
Accolade is an on-demand healthcare concierge for employers, health plans, health systems and consumers.
Accolade is an on-demand healthcare concierge for employers, health plans, health systems and consumers.
13
Funding: $329M
Everside Health is a direct primary care provider offering convenient on-site, near-site, and virtual care for its members.
Everside Health is a direct primary care provider offering convenient on-site, near-site, and virtual care for its members.
14
Funding: $328M
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
15
Funding: $324.9M
Accelerating the fight against cancer requires the entire industry to work together. Our products connect community oncologists, academics, hospitals, life science researchers and regulators on a shared technology platform. Flatiron Health gathers and analyzes data on cancer treatments and sells software based on those insights
Accelerating the fight against cancer requires the entire industry to work together. Our products connect community oncologists, academics, hospitals, life science researchers and regulators on a shared technology platform. Flatiron Health gathers and analyzes data on cancer treatments and sells software based on those insights
16
Funding: $315M
Redesign Health helps build, launch and find funding for digital health startups
Redesign Health helps build, launch and find funding for digital health startups
17
Funding: $274.5M
Medically Home is a services company that supplies remote care technology for at-home acute care
Medically Home is a services company that supplies remote care technology for at-home acute care
18
Funding: $259M
Evidation Health is a technology and services company that helps individuals and the world's most innovative healthcare companies understand and influence the everyday behaviors that create better health outcomes. Evidation pairs a first of its kind discovery engine designed for better, faster, and more efficient studies with a delivery platform, Achievement, that connects individuals and the healthcare industry, including life sciences organizations, providers, payers, and digital health companies.
Evidation Health is a technology and services company that helps individuals and the world's most innovative healthcare companies understand and influence the everyday behaviors that create better health outcomes. Evidation pairs a first of its kind discovery engine designed for better, faster, and more efficient studies with a delivery platform, Achievement, that connects individuals and the healthcare industry, including life sciences organizations, providers, payers, and digital health companies.
19
Funding: $256M
Truepill provides an API-connected healthcare infrastructure designed to revolutionize the patient experience.
Truepill provides an API-connected healthcare infrastructure designed to revolutionize the patient experience.
20
Funding: $238.7M
Rightway Healthcare combines cutting-edge patient navigation and analytics to optimize healthcare expenditure for employers and employees.
Rightway Healthcare combines cutting-edge patient navigation and analytics to optimize healthcare expenditure for employers and employees.
21
Funding: $203M
Qventus is an AI-based software platform that solves operational challenges across the hospital including emergency departments, perioperative areas, and patient safety.
Qventus is an AI-based software platform that solves operational challenges across the hospital including emergency departments, perioperative areas, and patient safety.
22
Funding: $186.1M
Cohere Health is changing the way patients, physicians and health plans work together. Our collaboration platform improves patient and physician experience, increases quality and reduces total cost of care.
Cohere Health is changing the way patients, physicians and health plans work together. Our collaboration platform improves patient and physician experience, increases quality and reduces total cost of care.
23
Funding: $183.3M
Kyruus delivers search and scheduling solutions for health systems to match patients with the right providers across the access points.
Kyruus delivers search and scheduling solutions for health systems to match patients with the right providers across the access points.
24
Funding: $181.6M
Phil is a B2B2C platform that provides end-to-end prescription management and delivery service.
Phil is a B2B2C platform that provides end-to-end prescription management and delivery service.
25
Funding: $174.8M
Trusted Health is reinventing the employment landscape for healthcare professionals with a digital employment platform built by nurses for nurses. Combining personal touch with modern technology, Trusted Health is building the future of work in healthcare by enabling nurses to seamlessly manage their careers.
Trusted Health is reinventing the employment landscape for healthcare professionals with a digital employment platform built by nurses for nurses. Combining personal touch with modern technology, Trusted Health is building the future of work in healthcare by enabling nurses to seamlessly manage their careers.
26
Funding: $171M
OM1 is a leading healthcare technology company focused on providing outcomes measurement. We’ve built an intelligent data cloud to enable different healthcare stakeholders to cost-effectively access, analyze, and use outcomes data in a more robust, clinically meaningful, and precise way.
OM1 is a leading healthcare technology company focused on providing outcomes measurement. We’ve built an intelligent data cloud to enable different healthcare stakeholders to cost-effectively access, analyze, and use outcomes data in a more robust, clinically meaningful, and precise way.
27
Funding: $161.7M
Augmedix is a tech-enabled service that allows doctors to focus on what matters most: patient care.
Augmedix is a tech-enabled service that allows doctors to focus on what matters most: patient care.
28
Funding: $159.1M
Luma Health solves the central challenge in healthcare - getting a patient in front of the right healthcare provider quickly. Luma provides no-fuss communication tools via text messaging and secure chat (yup, it's all HIPAA-compliant).
Luma Health solves the central challenge in healthcare - getting a patient in front of the right healthcare provider quickly. Luma provides no-fuss communication tools via text messaging and secure chat (yup, it's all HIPAA-compliant).
29
Funding: $145M
DexCare provides a Platform-as-a-Service offering to manage health system capacity and demand across all lines of care.
DexCare provides a Platform-as-a-Service offering to manage health system capacity and demand across all lines of care.
30
Funding: $135M
EasyHealth is connecting health coverage and care to improve health outcomes, rebuilding healthcare around people and data.
EasyHealth is connecting health coverage and care to improve health outcomes, rebuilding healthcare around people and data.
31
Funding: $112.3M
Solera allows health plans and employers to securely and efficiently leverage a network of community and digital health solutions.
Solera allows health plans and employers to securely and efficiently leverage a network of community and digital health solutions.
32
Funding: $109.8M
HealthJoy is an all-in-one healthcare guidance platform that helps employees make better decisions.
HealthJoy is an all-in-one healthcare guidance platform that helps employees make better decisions.
33
Funding: $95.5M
Vera Whole Health delivers primary care, acute care, and health coaching via on or near-site clinics.
Vera Whole Health delivers primary care, acute care, and health coaching via on or near-site clinics.
34
Funding: $95M
Our purpose is to make healthcare data useful. Software innovation will bring a dramatic jump in healthcare efficiency when consumers drive their own care. This saves lives. Maybe yours or mine someday—we’re all patients. This is why we get up in the morning and what’s inspiring in our work.
Our purpose is to make healthcare data useful. Software innovation will bring a dramatic jump in healthcare efficiency when consumers drive their own care. This saves lives. Maybe yours or mine someday—we’re all patients. This is why we get up in the morning and what’s inspiring in our work.
35
Funding: $95M
CodaMetrix is building an AI-powered platform for healthcare revenue cycle management
CodaMetrix is building an AI-powered platform for healthcare revenue cycle management
36
Funding: $91.3M
higi makes tracking your health simple, fun and rewarding. higi kiosks provide free screenings of your blood pressure, weight, pulse and body mass index.
higi makes tracking your health simple, fun and rewarding. higi kiosks provide free screenings of your blood pressure, weight, pulse and body mass index.
37
Funding: $77.3M
GNS Healthcare is a big data analytics company that empowers health plans, providers, pharmaceutical companies, and foundations to make intelligent data-driven decisions. GNS provides the analytic solutions that specifically predict the impact of interventions for each individual to improve overall population health and reduce costs.
GNS Healthcare is a big data analytics company that empowers health plans, providers, pharmaceutical companies, and foundations to make intelligent data-driven decisions. GNS provides the analytic solutions that specifically predict the impact of interventions for each individual to improve overall population health and reduce costs.
38
Funding: $56.9M
Xealth enables healthcare teams to order digital content and services as easily as they do medications today.
Xealth enables healthcare teams to order digital content and services as easily as they do medications today.
39
Funding: $56.5M
Oncology Analytics provides health plans with an evidence-based, technologically driven approach to utilization management. Their e-Prior Authorization platform is updated daily to accurately reflect more than 6,000 oncology treatment protocols for anti-cancer treatment across all cancer types and stages, including chemotherapy, radiation therapy, precision medicine, targeted therapy and supportive care.
Oncology Analytics provides health plans with an evidence-based, technologically driven approach to utilization management. Their e-Prior Authorization platform is updated daily to accurately reflect more than 6,000 oncology treatment protocols for anti-cancer treatment across all cancer types and stages, including chemotherapy, radiation therapy, precision medicine, targeted therapy and supportive care.
40
Funding: $55.5M
CipherHealth develops and implements SaaS based care-coordination solutions to simplify healthcare.
CipherHealth develops and implements SaaS based care-coordination solutions to simplify healthcare.
41
Funding: $46.9M
RxRevu helps patients save money on prescriptions by identifying the most effective medication at the best possible cost to providers.
RxRevu helps patients save money on prescriptions by identifying the most effective medication at the best possible cost to providers.
42
Funding: $45.5M
Sempre Health is bringing dynamic pricing to healthcare. This allows patients to afford care for longer, which directly improves clinical outcomes / quality measures while reducing utilization / cost.
Sempre Health is bringing dynamic pricing to healthcare. This allows patients to afford care for longer, which directly improves clinical outcomes / quality measures while reducing utilization / cost.
43
Funding: $44.4M
Prealize Health identifies next year’s new high cost members before a high cost event occurs.
Prealize Health identifies next year’s new high cost members before a high cost event occurs.
44
Funding: $42.2M
Health2047 Inc. develops and commercializes solutions to transform healthcare at the system level.
Health2047 Inc. develops and commercializes solutions to transform healthcare at the system level.
45
Funding: $42M
mPulse Mobile offers healthcare organizations consumer-focused mobile engagement solutions that improve member and patient engagement.
mPulse Mobile offers healthcare organizations consumer-focused mobile engagement solutions that improve member and patient engagement.
46
Funding: $41.6M
K4Connect is serving older adults & those living with disabilities via the integrated software platform that can integrate any number of disparate smart devices, systems and applications into a single responsive system. The company's initial K4-branded products, including the previously announced K4Community, are specifically tailored for seniors and individuals living with disabilities.
K4Connect is serving older adults & those living with disabilities via the integrated software platform that can integrate any number of disparate smart devices, systems and applications into a single responsive system. The company's initial K4-branded products, including the previously announced K4Community, are specifically tailored for seniors and individuals living with disabilities.
47
Funding: $36.6M
Human API is the world’s first real-time health data network, powering more than 10,000 applications in 40 countries. Human API enables your users to securely share their health data with your application, providing you with real-time access to digital, structured medical records and health data from thousands of clinics, labs, pharmacies, devices, and apps.
Human API is the world’s first real-time health data network, powering more than 10,000 applications in 40 countries. Human API enables your users to securely share their health data with your application, providing you with real-time access to digital, structured medical records and health data from thousands of clinics, labs, pharmacies, devices, and apps.
48
Funding: $36M
Yuvo Health supports the growth of Federally Qualified Health Centers (FQHCs) to provide quality care to communities in need.
Yuvo Health supports the growth of Federally Qualified Health Centers (FQHCs) to provide quality care to communities in need.
49
Funding: $36.1M
Parsley Health is redesigning primary care by creating boutique medical practice, integrating the latest in medical testing, technology and nutrition research.
Parsley Health is redesigning primary care by creating boutique medical practice, integrating the latest in medical testing, technology and nutrition research.
50
Funding: $35M
Aspen RxHealth is using a gig economy model to connect patients with pharmacists
Aspen RxHealth is using a gig economy model to connect patients with pharmacists
