Top 20 Healthcare optimization startups in USA
Nov 16, 2025
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21
1
Funding: $2B
Oscar is a health insurance company that employs technology, design, and data to humanize health care.
Oscar is a health insurance company that employs technology, design, and data to humanize health care.
3
Funding: $719M
Collective Health is creating the health insurance experience we all want and deserve. We’re starting by fixing what’s broken for US employers, who bear the brunt of most of our country’s private healthcare costs.
Collective Health is creating the health insurance experience we all want and deserve. We’re starting by fixing what’s broken for US employers, who bear the brunt of most of our country’s private healthcare costs.
4
Funding: $677.9M
Aledade is a primary care physician platform that provides everything doctors need to create and run an accountable care organization.
Aledade is a primary care physician platform that provides everything doctors need to create and run an accountable care organization.
5
Funding: $497M
Color provides a high-quality, physician-ordered, genetic test at a low cost. We include support for physicians, as well as genetic counseling as part of every purchase. Our goal is to expand physician-supported access to genetic testing for hereditary cancer risk to every person, everywhere.
Color provides a high-quality, physician-ordered, genetic test at a low cost. We include support for physicians, as well as genetic counseling as part of every purchase. Our goal is to expand physician-supported access to genetic testing for hereditary cancer risk to every person, everywhere.
6
Funding: $458.7M
Accolade is an on-demand healthcare concierge for employers, health plans, health systems and consumers.
Accolade is an on-demand healthcare concierge for employers, health plans, health systems and consumers.
7
Funding: $329M
Everside Health is a direct primary care provider offering convenient on-site, near-site, and virtual care for its members.
Everside Health is a direct primary care provider offering convenient on-site, near-site, and virtual care for its members.
8
Funding: $328M
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
Clarify Health Solutions develops analytics and software solutions that enable health systems to deliver more satisfying, better outcome and higher value care
9
Funding: $324.9M
Accelerating the fight against cancer requires the entire industry to work together. Our products connect community oncologists, academics, hospitals, life science researchers and regulators on a shared technology platform. Flatiron Health gathers and analyzes data on cancer treatments and sells software based on those insights
Accelerating the fight against cancer requires the entire industry to work together. Our products connect community oncologists, academics, hospitals, life science researchers and regulators on a shared technology platform. Flatiron Health gathers and analyzes data on cancer treatments and sells software based on those insights
10
Funding: $315M
Redesign Health helps build, launch and find funding for digital health startups
Redesign Health helps build, launch and find funding for digital health startups
11
Funding: $274.5M
Medically Home is a services company that supplies remote care technology for at-home acute care
Medically Home is a services company that supplies remote care technology for at-home acute care
12
Funding: $259M
Evidation Health is a technology and services company that helps individuals and the world's most innovative healthcare companies understand and influence the everyday behaviors that create better health outcomes. Evidation pairs a first of its kind discovery engine designed for better, faster, and more efficient studies with a delivery platform, Achievement, that connects individuals and the healthcare industry, including life sciences organizations, providers, payers, and digital health companies.
Evidation Health is a technology and services company that helps individuals and the world's most innovative healthcare companies understand and influence the everyday behaviors that create better health outcomes. Evidation pairs a first of its kind discovery engine designed for better, faster, and more efficient studies with a delivery platform, Achievement, that connects individuals and the healthcare industry, including life sciences organizations, providers, payers, and digital health companies.
13
Funding: $256M
Truepill provides an API-connected healthcare infrastructure designed to revolutionize the patient experience.
Truepill provides an API-connected healthcare infrastructure designed to revolutionize the patient experience.
14
Funding: $238.7M
Rightway Healthcare combines cutting-edge patient navigation and analytics to optimize healthcare expenditure for employers and employees.
Rightway Healthcare combines cutting-edge patient navigation and analytics to optimize healthcare expenditure for employers and employees.
15
Funding: $203M
Qventus is an AI-based software platform that solves operational challenges across the hospital including emergency departments, perioperative areas, and patient safety.
Qventus is an AI-based software platform that solves operational challenges across the hospital including emergency departments, perioperative areas, and patient safety.
16
Funding: $186.1M
Cohere Health is changing the way patients, physicians and health plans work together. Our collaboration platform improves patient and physician experience, increases quality and reduces total cost of care.
Cohere Health is changing the way patients, physicians and health plans work together. Our collaboration platform improves patient and physician experience, increases quality and reduces total cost of care.
17
Funding: $183.3M
Kyruus delivers search and scheduling solutions for health systems to match patients with the right providers across the access points.
Kyruus delivers search and scheduling solutions for health systems to match patients with the right providers across the access points.
18
Funding: $181.6M
Phil is a B2B2C platform that provides end-to-end prescription management and delivery service.
Phil is a B2B2C platform that provides end-to-end prescription management and delivery service.
19
Funding: $174.8M
Trusted Health is reinventing the employment landscape for healthcare professionals with a digital employment platform built by nurses for nurses. Combining personal touch with modern technology, Trusted Health is building the future of work in healthcare by enabling nurses to seamlessly manage their careers.
Trusted Health is reinventing the employment landscape for healthcare professionals with a digital employment platform built by nurses for nurses. Combining personal touch with modern technology, Trusted Health is building the future of work in healthcare by enabling nurses to seamlessly manage their careers.
20
Funding: $171M
OM1 is a leading healthcare technology company focused on providing outcomes measurement. We’ve built an intelligent data cloud to enable different healthcare stakeholders to cost-effectively access, analyze, and use outcomes data in a more robust, clinically meaningful, and precise way.
OM1 is a leading healthcare technology company focused on providing outcomes measurement. We’ve built an intelligent data cloud to enable different healthcare stakeholders to cost-effectively access, analyze, and use outcomes data in a more robust, clinically meaningful, and precise way.
