Serif Biomedicines
Updated: May 03, 2026
CEO - Jacob Rubens
Country: USA | Funding: $50M (+)
Founded: 2021
Website: https://serifbiomedicines.com
Serif Biomedicines uses circular DNA with certain chemical modifications to solve several problems that plague traditional gene therapy. Namely, the class of medicines provokes an immune response and is difficult to manufacture. Serif’s approach is to instead use modified DNA that is packaged inside of lipid nanoparticles. This DNA is accompanied by mRNA that, once inside the cell, is turned into proteins that shuttle the DNA into the nucleus, where it can itself be turned into a therapeutic protein.
Founded: 2021
Website: https://serifbiomedicines.com
Serif Biomedicines uses circular DNA with certain chemical modifications to solve several problems that plague traditional gene therapy. Namely, the class of medicines provokes an immune response and is difficult to manufacture. Serif’s approach is to instead use modified DNA that is packaged inside of lipid nanoparticles. This DNA is accompanied by mRNA that, once inside the cell, is turned into proteins that shuttle the DNA into the nucleus, where it can itself be turned into a therapeutic protein.
