Top 51 medical and healthcare startups in San Diego
May 03, 2026
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29
1
Funding: $247M
Ray Therapeutics is a biotech company that develops optogenetic gene therapies for patients with blinding diseases.
Ray Therapeutics is a biotech company that develops optogenetic gene therapies for patients with blinding diseases.
2
Funding: $109M
Neomorph develops "molecular glue" technology for binding drugs to tumor cell proteins and degrading these proteins to treat so far inaccessible targets. The company's degraders redirect cellular mechanisms known as E3 ubiquitin ligases to disease-causing proteins, leading to their degradation. This targeted protein degradation destroys the target protein by the 26S proteasome, thereby eliminating all associated biological activity. While heterobifunctional drugs still require a binding pocket on the target protein, "molecular glue" drugs bypass this requirement, thus offering a differentiated approach to drug development with different rules and the potential to target a broad spectrum of the proteome. The company is currently conducting clinical trials of its technology for the treatment of renal cell carcinoma.
Neomorph develops "molecular glue" technology for binding drugs to tumor cell proteins and degrading these proteins to treat so far inaccessible targets. The company's degraders redirect cellular mechanisms known as E3 ubiquitin ligases to disease-causing proteins, leading to their degradation. This targeted protein degradation destroys the target protein by the 26S proteasome, thereby eliminating all associated biological activity. While heterobifunctional drugs still require a binding pocket on the target protein, "molecular glue" drugs bypass this requirement, thus offering a differentiated approach to drug development with different rules and the potential to target a broad spectrum of the proteome. The company is currently conducting clinical trials of its technology for the treatment of renal cell carcinoma.
3
Funding: $95.3M
Turquoise Health is a health tech company that simplifies administration to reduce the expense and complexity of healthcare.
Turquoise Health is a health tech company that simplifies administration to reduce the expense and complexity of healthcare.
4
Funding: $1.6B
Crinetics Pharmaceuticals explores the inner life of GPCRs to discover and develop novel therapeutics targeting peptide hormone receptors for the treatment of rare endocrine disorders and endocrine-related cancers.
Crinetics Pharmaceuticals explores the inner life of GPCRs to discover and develop novel therapeutics targeting peptide hormone receptors for the treatment of rare endocrine disorders and endocrine-related cancers.
5
Funding: $799M
Samumed is a leader in medical research and development for tissue-level regeneration. With our platform's origins in small molecule-based Wnt pathway modulation, we develop therapeutics to address a range of degenerative diseases, regenerative medicine and oncology.
Samumed is a leader in medical research and development for tissue-level regeneration. With our platform's origins in small molecule-based Wnt pathway modulation, we develop therapeutics to address a range of degenerative diseases, regenerative medicine and oncology.
6
Funding: $737.6M
Rakuten Aspyrian is developing tumor-targeted precision therapies based on its proprietary platform Photoimmunotherapy.
Rakuten Aspyrian is developing tumor-targeted precision therapies based on its proprietary platform Photoimmunotherapy.
7
Funding: $460.5M
Poseida Therapeutics develops differentiated allogeneic cell therapies and genetic medicines using our proprietary genetic engineering platforms. The company develops the piggyBac non-viral DNA delivery system (which enables introduction of large genetic data into the genome) and the Cas-CLOVER site-specific gene editing system (which can be used for precise site-specific deletions, insertions and knockouts in various cell types). Using this platform, the company creates CAR-T therapies with high levels of desired TSCM (stem cell-derived memory T cells) for the treatment of a range of oncological, autoimmune and rare diseases, including multiple myeloma, acute myeloid leukemia and prostate cancer. Poseida was acquired by Roche in early 2025.
Poseida Therapeutics develops differentiated allogeneic cell therapies and genetic medicines using our proprietary genetic engineering platforms. The company develops the piggyBac non-viral DNA delivery system (which enables introduction of large genetic data into the genome) and the Cas-CLOVER site-specific gene editing system (which can be used for precise site-specific deletions, insertions and knockouts in various cell types). Using this platform, the company creates CAR-T therapies with high levels of desired TSCM (stem cell-derived memory T cells) for the treatment of a range of oncological, autoimmune and rare diseases, including multiple myeloma, acute myeloid leukemia and prostate cancer. Poseida was acquired by Roche in early 2025.
8
Funding: $418M
RayzeBio is focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes.
RayzeBio is focused on improving outcomes for people with cancer by harnessing the power of targeted radioisotopes.
9
Funding: $369.8M
Human Longevity is the genomics-based, technology-driven company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries to revolutionize the practice of medicine.
Human Longevity is the genomics-based, technology-driven company creating the world’s largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries to revolutionize the practice of medicine.
10
Funding: $340M
Capstan Therapeutics is advancing cell engineering to develop CAR-T therapeutics for a broad range of diseases.
Capstan Therapeutics is advancing cell engineering to develop CAR-T therapeutics for a broad range of diseases.
11
Funding: $332M
ADARx Pharmaceuticals is a genetic medicine company focusing on the base editing of mRNA transcripts.
ADARx Pharmaceuticals is a genetic medicine company focusing on the base editing of mRNA transcripts.
12
Funding: $303M
Iambic Therapeutics is built on technologies for predicting protein-ligand structures, generating molecular designs and other drug discovery tasks. Using the technologies, Iambic claims it can accelerate drug discovery, pointing to the two years it took to take its lead project from program launch to IND to make its case.
Iambic Therapeutics is built on technologies for predicting protein-ligand structures, generating molecular designs and other drug discovery tasks. Using the technologies, Iambic claims it can accelerate drug discovery, pointing to the two years it took to take its lead project from program launch to IND to make its case.
13
Funding: $276.3M
Biolinq develops skin-applied electronic sensors. Finally, people with diabetes will have a better CGM experience that is not only more affordable, but also pain-free.
Biolinq develops skin-applied electronic sensors. Finally, people with diabetes will have a better CGM experience that is not only more affordable, but also pain-free.
14
Funding: $272M
Aspen Neuroscience is a private biotechnology company that uses innovative genomic approaches combined with stem cell biology.
Aspen Neuroscience is a private biotechnology company that uses innovative genomic approaches combined with stem cell biology.
15
Funding: $260M
Neurocrine Biosciences engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases.
Neurocrine Biosciences engages in the discovery and development of drugs for the treatment of neurological and endocrine-related diseases.
16
Funding: $255M
Cortica provides neurological therapies for children with autism and other developmental differences.
Cortica provides neurological therapies for children with autism and other developmental differences.
17
Funding: $237.5M
Escient Pharmaceuticals is a provider of bio-technical research and development services intended to focus in advancement of first-in-class G Protein-Coupled Receptor targeted drugs. The company's services focuses on offering therapies for neuro-immuno-inflammatory and autoreactive diseases
Escient Pharmaceuticals is a provider of bio-technical research and development services intended to focus in advancement of first-in-class G Protein-Coupled Receptor targeted drugs. The company's services focuses on offering therapies for neuro-immuno-inflammatory and autoreactive diseases
18
Funding: $225.1M
Plexium is a drug development startup that leverages techniques from various physical-science and computational disciplines.
Plexium is a drug development startup that leverages techniques from various physical-science and computational disciplines.
19
Funding: $221M
Engrail Therapeutics is a developer of medicines to transform the lives of patients with life-limiting diseases of the nervous system.
Engrail Therapeutics is a developer of medicines to transform the lives of patients with life-limiting diseases of the nervous system.
20
Funding: $213.1M
Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral
Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral
21
Funding: $198M
Artiva Biotherapeutics is an oncology company focused on developing and commercializing allogeneic natural killer (NK) cell therapies.
Artiva Biotherapeutics is an oncology company focused on developing and commercializing allogeneic natural killer (NK) cell therapies.
22
Funding: $185.9M
AnaptysBio is a therapeutic antibody product company and the leader in the use of somatic hypermutation, or SHM, for antibody discovery and optimization. SHM is the body's natural process for generating potent antibodies to fight disease.
AnaptysBio is a therapeutic antibody product company and the leader in the use of somatic hypermutation, or SHM, for antibody discovery and optimization. SHM is the body's natural process for generating potent antibodies to fight disease.
23
Funding: $185.2M
Arthrosi Therapeutics is a biotechnology company that focuses on drug discovery and development.
Arthrosi Therapeutics is a biotechnology company that focuses on drug discovery and development.
25
Funding: $154.8M
Genalyte is guided by the vision of taking a single drop of blood, performing panels of tests and returning accurate and reproducible results within a few minutes.
Genalyte is guided by the vision of taking a single drop of blood, performing panels of tests and returning accurate and reproducible results within a few minutes.
26
Funding: $117.5M
At Organovo, we design and create functional human tissues using our proprietary three-dimensional bioprinting technology. Our goal is to build living human tissues that are proven to function like native tissues. With reproducible 3D tissues that accurately represent human biology, we are enabling ground-breaking therapies by:
At Organovo, we design and create functional human tissues using our proprietary three-dimensional bioprinting technology. Our goal is to build living human tissues that are proven to function like native tissues. With reproducible 3D tissues that accurately represent human biology, we are enabling ground-breaking therapies by:
27
Funding: $74M
Truvian is a transformational diagnostic company bringing lab-accurate results to the point-of-action where consumers engage healthcare providers to lead healthier lives.
Truvian is a transformational diagnostic company bringing lab-accurate results to the point-of-action where consumers engage healthcare providers to lead healthier lives.
28
Funding: $64.3M
Arnatar Therapeutics is a biopharmaceutical company that specializes in the development of novel nucleic acid medications.
Arnatar Therapeutics is a biopharmaceutical company that specializes in the development of novel nucleic acid medications.
29
Funding: $58.5M
Concert Health offers behavioral health services to primary care practices
Concert Health offers behavioral health services to primary care practices
30
Funding: $55M
Replay is a genome writing company reprogramming biology by writing and delivering big DNA.
Replay is a genome writing company reprogramming biology by writing and delivering big DNA.
31
Funding: $53.4M
AristaMD is a healthcare company that features a software platform that helps hospitals and practitioners on improving patient outcomes.
AristaMD is a healthcare company that features a software platform that helps hospitals and practitioners on improving patient outcomes.
33
Funding: $40M
Creyon Bio is a drug development company engineering RNA-based medicines and their components.
Creyon Bio is a drug development company engineering RNA-based medicines and their components.
34
Funding: $34.8M
Aethlon Medical creates immunotherapeutic devices to combat infectious disease and cancer.
Aethlon Medical creates immunotherapeutic devices to combat infectious disease and cancer.
35
Funding: $27M
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
36
Funding: $26M
Vironexis is focused on transforming the future of cancer treatment by pioneering AAV-delivered T-cell immunotherapy.
Vironexis is focused on transforming the future of cancer treatment by pioneering AAV-delivered T-cell immunotherapy.
37
Funding: $23M
Vessel is an at-home wellness tracker that helps in accessing, understanding, and optimizing health and wellness from the comfort of home.
Vessel is an at-home wellness tracker that helps in accessing, understanding, and optimizing health and wellness from the comfort of home.
38
Funding: $20.2M
Tolerance Bio is a biopharmaceutical company focused on manipulating immune tolerance via the thymus.
Tolerance Bio is a biopharmaceutical company focused on manipulating immune tolerance via the thymus.
40
Funding: $18M
Headlight is a mental health firm that aims to change the way mental health services are delivered.
Headlight is a mental health firm that aims to change the way mental health services are delivered.
42
Funding: $14.4M
Spinogenix is a developer of a new class of therapeutics for neurodegenerative and psychiatric diseases.
Spinogenix is a developer of a new class of therapeutics for neurodegenerative and psychiatric diseases.
43
Funding: $2.4M
Nanomedical Diagnostics is the first company to combine expertise in biology, nanotechnology, surface chemistry, engineering, and manufacturing to create practical and scaleable graphene biological field effect transistor (BioFET) products. Our ongoing mission is applying our cutting-edge capabilities to produce affordable diagnostic and monitoring platforms that deliver accurate, timely health information and improve patient outcomes and lives.
Nanomedical Diagnostics is the first company to combine expertise in biology, nanotechnology, surface chemistry, engineering, and manufacturing to create practical and scaleable graphene biological field effect transistor (BioFET) products. Our ongoing mission is applying our cutting-edge capabilities to produce affordable diagnostic and monitoring platforms that deliver accurate, timely health information and improve patient outcomes and lives.
44
Funding: $6.4M
Acurion develops AI-powered oncology precision medicine platform OncoGaze that analyzes genomic biomarkers from routine clinical slides to help clinicians select personalized therapies. The company says OncoGaze can detect genomic biomarkers from routine clinical slides for every cancer, allowing for real-time therapy selection.
Acurion develops AI-powered oncology precision medicine platform OncoGaze that analyzes genomic biomarkers from routine clinical slides to help clinicians select personalized therapies. The company says OncoGaze can detect genomic biomarkers from routine clinical slides for every cancer, allowing for real-time therapy selection.
45
Funding: $6M
Sleep Data develops virtual care platform BetterNight catered to people with sleep apnea, insomnia, anxiety, jet lag, stress and other sleep conditions.
Sleep Data develops virtual care platform BetterNight catered to people with sleep apnea, insomnia, anxiety, jet lag, stress and other sleep conditions.
46
Funding: $5.1M
Cari Health develops remote medication monitors that allow clinicians to precision dose and increase adherence to lifesaving therapeutics.
Cari Health develops remote medication monitors that allow clinicians to precision dose and increase adherence to lifesaving therapeutics.
48
Iron Horse Therapeutics is developing treatments for amyotrophic lateral sclerosis (ALS) with compounds that modulate the activity of EphA4. Humans with EphA4 mutations that decrease its activity or reduced EphA4 expression levels exhibit prolonged survival and reduced disease severity. Similar results have been demonstrated in ALS mouse and rat animal models.
49
Funding: $3M
Chromis Therapeutics develops curative treatments for chronic HBV infection, based on its advanced proprietary drug design and discovery platform.
Chromis Therapeutics develops curative treatments for chronic HBV infection, based on its advanced proprietary drug design and discovery platform.
50
Funding: $2.1M
Hifinite is a full stack digital healthcare solutions provider. We empower and enable our partners with a suite of applications to manage chronic diseases, increase medication adherence, offer on-demand telemedicine services, improve corporate wellness, and manage clinical trials.
Hifinite is a full stack digital healthcare solutions provider. We empower and enable our partners with a suite of applications to manage chronic diseases, increase medication adherence, offer on-demand telemedicine services, improve corporate wellness, and manage clinical trials.
