Top 13 Liver Disease treatment startups

Updated: Nov 19, 2025
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These startups develop new treatments and diagnostics technologies for fatty liver disease, nonalcoholic steatohepatitis (NASH), liver fibrosis and other liver diseases.
1
Moderna Therapeutics
Country: USA | Funding: $3.9B
Moderna is a pioneer in developing a new class of drugs based on messenger RNA (mRNA). This new drug platform is based on the discovery that in-vitro engeneered and injected mRNA can direct the body's cellular machinery to produce virtually any protein of interest, from native proteins to antibodies and other entirely new protein constructs with therapeutic activity both inside and outside cells. In other words, mRNA can guide the body to produce its own drugs. Moderna used mRNA to create the first COVID-19 vaccine and is now applying this technology to create vaccines for infectious diseases (influenza, RSV, HSV, etc.), immuno-oncology (melanoma, lung cancer, liver cancer, etc.), rare diseases and autoimmune diseases.
2
Madrigal Pharmaceuticals
Country: USA | Funding: $1.9B
The Company is targeting treatment of both niche and prevalent indications, including fatty liver disease.
3
Akero Therapeutics
Country: USA | Funding: $951.1M
Akero Therapeutics is a biotechnology company focused on reversing the NASH epidemic by restoring the body’s metabolism to a balanced state.
4
Mirum Pharmaceuticals
Country: USA | Funding: $497M
Mirum Pharmaceuticals develops drugs for rare cholestatic liver diseases.
5
Alentis Therapeutics
Country: Switzerland | Funding: $365.4M
ALENTIS Therapeutics is a Swiss-French biotech company developing novel therapeutics in advanced liver disease and cancer.
6
AgomAb Therapeutics
Country: Belgium | Funding: $325.6M
AgomAb Therapeutics is a Company is developing growth factor-mimetic agonistic monoclonal antibodies to regenerate damaged tissues.
7
Arbor Biotechnologies
Country: USA | Funding: $304.5M
Arbor Biotechnologies is an operator of a bio-discovery company intended to provide human diagnostic development services.
8
Enyo Pharma
Country: France | Funding: €103.5M
ENYO Pharma is a clinical stage Biotech with a unique drug discovery engine inspired by viruses. In particular it develops drug for Chronic Hepatitis B.
9
Inipharm
Country: USA | Funding: $35M
Inipharm is building on novel insights and applying our chemistry expertise to develop therapies for patients with liver disease.
10
Pandorum Technologies
Country: India | Funding: $24.6M
Pandorum Technologies is a biotechnology startup with a distinct synergy of life science and engineering competences focused on tissue engineering. The company uses its proprietary technology platforms to design and manufacture functional, three-dimensional living human tissues; intended for medical research, therapeutic and other applications.
11
In Diagnostics
Country: USA | Funding: $3M
In Diagnostics is developing next generation disposable lab-quality spectrophotometer that rely on digital microchips to analyze biological samples.
12
Cyberliver
Country: UK
Cyberliver is a company that focuses on delivering cutting edge solutions for liver care via use of innovative technology.
13
Genevant Sciences
Country: Canada
Genevant brings world-class delivery platforms that include best-in-class lipid nanoparticle (LNP) technology and next generation ligand conjugate technology, the industry’s most robust and expansive LNP patent estate, decades of experience and expertise in nucleic acid drug development headed by the team that enabled delivery for the world’s only approved small interfering RNA (siRNA)-LNP product, and an innovative culture that positions us to maintain our leadership for years to come.
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Jason Kwon
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com