Top 20 Eye Disease and Blindness treatment startups in USA
Nov 14, 2025
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24
1
Funding: $100M
Ollin is dedicated to advancing novel therapeutic candidates that target a broader spectrum of biology to improve outcomes for patients with severe, vision-threatening conditions.
Ollin is dedicated to advancing novel therapeutic candidates that target a broader spectrum of biology to improve outcomes for patients with severe, vision-threatening conditions.
2
Funding: $513M
Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients (including with Thyroid Eye Disease ).
Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients (including with Thyroid Eye Disease ).
3
Funding: $763.8M
Spark is a leader in the field of gene therapy, seeking to transform the lives of patients by developing potential one-time, life-altering treatments for debilitating genetic diseases. We initially are applying our integrated platform to treat rare diseases where no, or only palliative, therapies exist.
Spark is a leader in the field of gene therapy, seeking to transform the lives of patients by developing potential one-time, life-altering treatments for debilitating genetic diseases. We initially are applying our integrated platform to treat rare diseases where no, or only palliative, therapies exist.
4
Funding: $694.9M
Pliant Therapeutics is focused on discovering, developing and commercializing breakthrough treatments for fibrotic diseases.
Pliant Therapeutics is focused on discovering, developing and commercializing breakthrough treatments for fibrotic diseases.
5
Funding: $317.8M
Emendo Biotherapeutics develops gene editing platform to expand the list of diseases amenable to treatment with gene editing, resulting in a pipeline of hematology and ophthalmology programs.
Emendo Biotherapeutics develops gene editing platform to expand the list of diseases amenable to treatment with gene editing, resulting in a pipeline of hematology and ophthalmology programs.
7
Funding: $173.4M
IDx is a leading AI diagnostics company on a mission to transform the quality, accessibility, and affordability of healthcare. The company’s first product, IDx-DR, is an FDA-cleared AI-based diagnostic system designed for use at the front lines of care to detect diabetic retinopathy. IDx is developing additional AI-based diagnostic algorithms for the detection of macular degeneration, glaucoma, Alzheimer’s disease, cardiovascular disease, and stroke risk.
IDx is a leading AI diagnostics company on a mission to transform the quality, accessibility, and affordability of healthcare. The company’s first product, IDx-DR, is an FDA-cleared AI-based diagnostic system designed for use at the front lines of care to detect diabetic retinopathy. IDx is developing additional AI-based diagnostic algorithms for the detection of macular degeneration, glaucoma, Alzheimer’s disease, cardiovascular disease, and stroke risk.
8
Funding: $162.7M
Meira Gene Therapy is argeting inherited retinal diseases with therapies designed to halt vision loss.
Meira Gene Therapy is argeting inherited retinal diseases with therapies designed to halt vision loss.
9
Funding: $120M
Character Bio is a platform that merges genomics with clinical data and AI technology, focusing on patients affected by AMD.
Character Bio is a platform that merges genomics with clinical data and AI technology, focusing on patients affected by AMD.
10
Funding: $120M
Aurion Biotechnologies is on mission is to cure leading forms of blindness and transform the lives of millions of patients, by developing a platform of advanced therapies to treat ocular diseases.
Aurion Biotechnologies is on mission is to cure leading forms of blindness and transform the lives of millions of patients, by developing a platform of advanced therapies to treat ocular diseases.
11
Funding: $104.8M
Claris works to improve lives by uniting unmet needs in ophthalmology with robust science and data-driven decision making
Claris works to improve lives by uniting unmet needs in ophthalmology with robust science and data-driven decision making
12
Funding: $57M
EyeQue is a maker of at home visual acuity tests. Dedicated to inspiring people to learn about & care for their eyes by putting affordable, accurate vision tests directly into their hands.
EyeQue is a maker of at home visual acuity tests. Dedicated to inspiring people to learn about & care for their eyes by putting affordable, accurate vision tests directly into their hands.
13
Funding: $56M
Visus Therapeutics is a clinical-stage pharmaceutical company lighting the way to dramatically improve patient lives through the development of differentiated, best-in-class ophthalmic therapies.
Visus Therapeutics is a clinical-stage pharmaceutical company lighting the way to dramatically improve patient lives through the development of differentiated, best-in-class ophthalmic therapies.
14
Funding: $55.3M
XP Health is an artificial intelligence-powered vision benefits platform for employees.
XP Health is an artificial intelligence-powered vision benefits platform for employees.
15
Funding: $46.8M
Surface Pharmaceuticals intends to advance state of the art treatments for ocular surface diseases.
Surface Pharmaceuticals intends to advance state of the art treatments for ocular surface diseases.
16
Funding: $47.4M
Eyenuk, Inc. is a global digital health company and leader in real-world AI eye screening for autonomous disease detection
Eyenuk, Inc. is a global digital health company and leader in real-world AI eye screening for autonomous disease detection
17
Funding: $43.1M
Opternative builds online eye exam, the most convenient way to get a prescription from an ophthalmologist for contacts and glasses. The exam can be taken from anywhere, at any time, and a doctor issued prescription can be used to shop everywhere. Eye exams for glasses and contact prescriptions are just the beginning. We envision a world where technology allows patients and doctors to connect to make all aspects of vision care more convenient, accessible and even fun!
Opternative builds online eye exam, the most convenient way to get a prescription from an ophthalmologist for contacts and glasses. The exam can be taken from anywhere, at any time, and a doctor issued prescription can be used to shop everywhere. Eye exams for glasses and contact prescriptions are just the beginning. We envision a world where technology allows patients and doctors to connect to make all aspects of vision care more convenient, accessible and even fun!
18
Funding: $42.4M
Abpro Therapeutics develops antibody drugs for cancer and vascular eye disease
Abpro Therapeutics develops antibody drugs for cancer and vascular eye disease
20
Funding: $26M
Simple Contacts allows you to take a vision test and reorder your contacts In just five minutes, without the office visit.
Simple Contacts allows you to take a vision test and reorder your contacts In just five minutes, without the office visit.
