Top 16 Clinical Decision Support startups in USA
Nov 18, 2025
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16
1
Funding: $319.3M
Ambience Healthcare is the leading AI operating system for healthcare organizations.
Ambience Healthcare is the leading AI operating system for healthcare organizations.
2
Funding: $81.4M
Regard uses AI to automatically diagnose patients and generate accurate notes for doctors to improve patient care and reduce burnout.
Regard uses AI to automatically diagnose patients and generate accurate notes for doctors to improve patient care and reduce burnout.
3
Funding: $66.5M
Prognos is a healthcare AI company focused on eradicating disease by driving decisions earlier in healthcare in collaboration with payers, Life Sciences and diagnostics companies. The Prognos Registry is the largest source of clinical diagnostics information in over 30 disease areas, with over 5B medical records for 100M patients. Prognos has 500 extensive proprietary and learning clinical algorithms to enable earlier patient identification for enhanced treatment decision-making, risk management and quality improvement.
Prognos is a healthcare AI company focused on eradicating disease by driving decisions earlier in healthcare in collaboration with payers, Life Sciences and diagnostics companies. The Prognos Registry is the largest source of clinical diagnostics information in over 30 disease areas, with over 5B medical records for 100M patients. Prognos has 500 extensive proprietary and learning clinical algorithms to enable earlier patient identification for enhanced treatment decision-making, risk management and quality improvement.
4
Funding: $64.3M
Summus Global is a virtual specialist platform that brings personalized advice to every medical decision.
Summus Global is a virtual specialist platform that brings personalized advice to every medical decision.
5
Funding: $44M
Canvas is the first and only human-centered EMR, built to enable better clinical decisions, superior patient care, and achievable work-life balance.
Canvas is the first and only human-centered EMR, built to enable better clinical decisions, superior patient care, and achievable work-life balance.
6
Funding: $26.6M
Story Health helps specialists to understand medical situations and make clinical decisions that are through virtual protocols.
Story Health helps specialists to understand medical situations and make clinical decisions that are through virtual protocols.
7
Funding: $25M
Layer Health is a platform that enables the healthcare industry to correctly, scalably, and reliably extract the insights from health data.
Layer Health is a platform that enables the healthcare industry to correctly, scalably, and reliably extract the insights from health data.
8
Funding: $12.7M
Ambient Clinical Analytics sells clinical decision support systems to hospitals to reduce overall health care costs and improve patient outcomes.
Ambient Clinical Analytics sells clinical decision support systems to hospitals to reduce overall health care costs and improve patient outcomes.
9
Funding: $12.8M
InsightRX is a software platform that incorporates the principles of quantitative pharmacology and machine learning to provide an individualized understanding of a patient’s response to treatment. It delivers its technology in the form of easy-to-use clinical decision support tools at the point-of-care to help guide treatment decision-making. The platform guides treatment decisions at both the individual level and the population level.
InsightRX is a software platform that incorporates the principles of quantitative pharmacology and machine learning to provide an individualized understanding of a patient’s response to treatment. It delivers its technology in the form of easy-to-use clinical decision support tools at the point-of-care to help guide treatment decision-making. The platform guides treatment decisions at both the individual level and the population level.
10
Funding: $10M
Mednition offers a machine learning-powered decision support solution for hospitals. It provides real-time analytics solutions to the Health Care community and brings together health care information and machine learning to improve patient outcomes, lower risk, and reduce costs for health care providers.
Mednition offers a machine learning-powered decision support solution for hospitals. It provides real-time analytics solutions to the Health Care community and brings together health care information and machine learning to improve patient outcomes, lower risk, and reduce costs for health care providers.
11
Funding: $8.5M
SaVia Health develops software that provides real decision support to clinicians at the point of care.
SaVia Health develops software that provides real decision support to clinicians at the point of care.
12
Funding: $8M
AvoMD is reimagining decision support with no code software and point-of-care innovation.
AvoMD is reimagining decision support with no code software and point-of-care innovation.
13
Funding: $7M
Glass Health empowers clinicians with a platform for AI-assisted diagnosis and clinical decision-making
Glass Health empowers clinicians with a platform for AI-assisted diagnosis and clinical decision-making
14
Funding: $6M
Keebler Health is a developer of an AI-based risk adjustment tool for healthcare providers.
Keebler Health is a developer of an AI-based risk adjustment tool for healthcare providers.
15
Funding: $4.6M
By harnessing the power of patient outcomes data, latest medical research, and cutting-edge technology, Remedy Logic builds extremely accurate diagnosis AI-tools to improve medical decision making and to reduce diagnosis errors globally.
By harnessing the power of patient outcomes data, latest medical research, and cutting-edge technology, Remedy Logic builds extremely accurate diagnosis AI-tools to improve medical decision making and to reduce diagnosis errors globally.
16
Funding: $3.9M
AESOP offers two AI-powered solutions: RxPrime, a medication decision support tool, and a clinical documentation improvement tool for spotting incorrect diagnoses
AESOP offers two AI-powered solutions: RxPrime, a medication decision support tool, and a clinical documentation improvement tool for spotting incorrect diagnoses
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