Top 20 Clinical trials startups in USA

Sep 30, 2025 | By Jason Kwon

1
Funding: $506.6M
Medable's platform helps to facilitate the clinical trial process. Its mission is to reduce clinical trial timelines by 50%.
2
Funding: $479.6M
Reify Health is a cloud-based software company that develops tools for the clinical trial ecosystem.
3
Funding: $347.5M
Science 37 is making the promise of virtual trials the new reality. By engaging with patients from the comfort of their own home, the company provides access to patients who can never be reached by traditional site-based research models.
4
Funding: $258M
TrialSpark is a technology company that helps bring treatments to patients faster by reimagining how clinical trials are run.
5
Funding: $252.1M
4G Clinical provides software and services for clinical drug trials specifically in randomization and trial supply management (RTSM).
6
Funding: $203M
Paradigm is building a platform that aims to streamline the clinical trial process for patients and connect biopharmaceutical trial sponsors and healthcare providers.
7
Funding: $196M
Elligo Health Research is revolutionizing the clinical research industry with a novel approach to common trial challenges including patient participation and enrollment, and physician participation. They provide physicians and their patients the opportunity to participate in clinical trials using advanced health care informatics.
8
Funding: $134.9M
Unlearn.AI accelerates drug development by pioneering computational clinical trials.
9
Funding: $115.8M
Florence advances clinical research through software by connecting trial sites with pharmaceutical sponsors.
10
Funding: $111M
Vial is a tech-enabled CRO delivering superior clinical trial outcomes.
11
Funding: $68.8M
AiCure's mission is to equip patients, researchers and providers with the intelligence to understand the exact link between medication and health. By 2020, there will be 6 billion smartphones in use. AiCure is leveraging this technology by combining it with Artificial Intelligence to bring better health, better drugs, and better treatment to those who need it the most.
12
Funding: $66M
Teckro is a life science technology company that is rethinking every element of clinical research.
13
Funding: $65M
PhaseV provides AI-driven solutions for efficient clinical development and operations.
14
Funding: $57.6M
Curebase is a provider of decentralized clinical research software solutions and services to patients and medical providers.
15
Funding: $50M
THREAD is a singular, fully configurable decentralized clinical trial platform with services that deliver global scalability and rapid flexibility from study design to close-out
16
Funding: $46.8M
SubjectWell is the risk-free clinical trials marketplace for patient recruitment
17
Funding: $35M
Faro has developed software that allows rapid evaluation of clinical study costs, accessibility to patients and ease of study conduct
18
Funding: $29M
Lokavant is an IT firm that offers real-time visualizations, risk alerts, artificial intelligence, and human insight services.
19
Funding: $27.5M
Topography focuses on creating a new topography of health.
20
Funding: $27.7M
TrialJectory's mission is to use AI to transform the world of cancer care. By being the leading personalised, AI-based clinical trials data platform, the company partners with industry leaders to expedite new treatments into the market.
Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com