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Top 11 Chronic back pain treatment startups in USA
Oct 28, 2025 | By Jason Kwon | 18 |
1
Funding: $1B
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
Hinge Health is pioneering digital care programs for people with chronic musculoskeletal conditions such as back or joint pain
2
Funding: $411.3M
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
Eliem Therapeutics plans to treat chronic pain, depression, epilepsy and anxiety with palmitoylethanolamide (PEA) prodrug
3
Funding: $188.8M
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
SPR Therapeutics is a medical device company that develops peripheral nerve stimulation products for pain management clinicians.
4
Funding: $150M
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
Operator of a drug discovery company intended to develop novel, non-opioid therapies for chronic pain.
5
Funding: $134.2M
SiteOne Therapeutics is a biopharmaceutical company that develops pain therapeutics to treat sensory hyperexcitability disorders.
SiteOne Therapeutics is a biopharmaceutical company that develops pain therapeutics to treat sensory hyperexcitability disorders.
6
Funding: $71M
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
AppliedVR offers virtual reality-based therapeutic treatments that address the complexity of chronic pain.
7
Funding: $28.4M
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
Wavegate is a medical technology company developing internally-generated intellectual property (IP) pertaining to neuromodulation.
8
Funding: $27M
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
Data driven MSK solution for systems and payers who want to eliminate unnecessary surgery, lower opioid usage and drive higher outcomes.
9
Funding: $20M
Clearing is a healthcare platform focused on providing opioid-free pain relief.
Clearing is a healthcare platform focused on providing opioid-free pain relief.
10
Funding: $19M
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
Artelo Biosciences aims to accelerate the development and commercialization of endocannabinoid system modulating therapeutics.
11
NeuroTechnology develops CORDUS appliance that helps to treat effectively back pain
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