Top 16 Breast cancer treatment startups in USA

Sep 30, 2025 | By Jason Kwon

1
Funding: $256M
Acepodia is a therapeutics company that employs flexible therapeutic design to treat cancer.
2
Funding: $220M
Paige.AI, stands for Pathology AI Guidance Engine, is a new startup that uses artificial intelligence to fight cancer. The company focus on breast, prostrate and other major cancers, and expects to partner with other medical centers beyond MSK, as well as commercial labs and pharmaceutical companies as it grows and develops its applications.
3
Funding: $208.3M
Halda is developing RIPTAC therapeutics - a new class of precision medicines to defeat cancer.
4
Funding: $187M
Callio Therapeutics develops next-generation, multi-payload antibody-drug conjugates (ADCs).
5
Funding: $112.3M
iMDx is focused on cancers with large patient populations and significant unmet need. The company is developing three genetic tests – blood tests for breast cancer and lung cancer, and a urine-based test for bladder cancer.
6
Funding: $106M
Totus Medicines is a provider of chemical biology technologies by creating life-changing covalent drugs.
7
Funding: $95M
Osiris Therapeutics is a stem cell company, which focuses on developing and marketing products to treat medical conditions in the inflammatory, cardiovascular, orthopedic and wound healing markets. The company operates its business through two segments: Therapeutics and Biosurgery segment. The Therapeutics segment focuses on developing biologic stem cell drug candidates from readily available and non-controversial sources. One of its products, Stromagen was used to treat breast cancer in clinical trials.
8
Funding: $65M
Actuate Therapeutics is a biopharmaceutical company focused on the development of compounds for use in the treatment of cancer, and inflammatory diseases leading to fibrosis and neurodegeneration. Our work has led to some fascinating results around anti-tumor activity in the brain, pancreas, lungs, and breasts.
9
Funding: $34.3M
Anixa is a publicly-traded biotechnology company focused on harnessing the body's immune system in the fight against cancer. Anixa's therapeutic portfolio includes a cancer vaccine technology focused on the immunization against α-Lactalbumin to prevent triple negative breast cancer (TNBC), as well as a cancer immunotherapy program which uses a novel type of CAR-T, known as chimeric endocrine receptor T-cell (CER-T) technology.
10
Funding: $18.8M
4D Path uses H&E biopsy images to unveil hidden data instantly providing biomarker profiling and stratification. Although their initial focus is on breast cancer, the company is actively working on developing products for ovarian cancer, cervical cytology, skin cancer, and, in general, around immunotherapy in various cancers.
11
Funding: $5.9M
Cyrcadia Health, creator of the iTbra, offers a discreet insert that goes under any bra, and empowers women to enhance their monthly breast self-exam in their own home. Their patches detect circadian temperature changes within breast tissue, and uses machine-learning algorithms to collect data and communicate it to Cyrcadia Health.
12
Funding: $5.4M
iSono Health develops a wearable solution to monitor breast health.
13

CureMetrix offers a next generation of medical image analysis for Mammography.
14
Funding: $3.7M
TeVido BioDevices uses the innovative process of 3D bio-printing of living human cells for use as implants or grafts targeting use in reconstructive surgery and wound care. TeVido will change the way reconstructive surgery is approached, starting by improving options for breast cancer survivors but expanding capability to others who suffer disfigurement and long to improve their self-esteem.
15
Funding: $625K
Accuronix Therapeutics is a biotech company that develops drug targeting technology to resolve issues in cancer therapy. The startup’s lead candidate ACXT-3102, enables effective ligand binding to deliver targeted cytotoxic payloads in patients suffering from pancreatic adenocarcinoma. Accuronix also is developing MTDCs for other types of cancers such as breast or brain cancer.
16

Whiterabbit has developed a line of products targeting the mammography space to enable early and accurate breast cancer detection.
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Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com