Top 5 Rheumatoid Arthritis treatment startups in USA

Mar 19, 2026
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1
Nimbus Therapeutics
Funding: $637M
Nimbus Therapeutics is pioneering a new computational technology-driven paradigm to rapidly advance a diverse pipeline of novel small molecule product candidates into clinical development. We are designing highly selective and potent medicines to disrupt known drivers of serious diseases, including metabolic disease, cancer and immune-inflammatory disorders.
2
Acelyrin
Funding: $558M
ACELYRIN is a biopharma company that identifies, acquires, and accelerates the development and commercialization of life-changing inflammatory-disease-focused therapies.
3
SetPoint Medical
Funding: $496.4M
SetPoint Medical treats patients with debilitating inflammatory diseases using proprietary implantable bioelectronic devices.
4
Evelo Biosciences
Funding: $397M
Evelo is pioneering therapies that modulate systemic immune response by acting on the gut-body network - monoclonal microbials. They have the potential to treat many diseases, including inflammatory disease, cancer, autoimmune disease, metabolic, neurobehavior and neuroinflammatory diseases.
5
AltruBio
Funding: $327.6M
AltruBio develops antibody-targeted therapies for psoriatic arthritis and ulcerative colitis
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Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com