Top 10 medical and healthcare startups in Minneapolis

Dec 16, 2025
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1
Gravie
Funding: $532.6M
Gravie is an insurance company that designs health benefits plans for small and midsize employers.
2
CVRX
Funding: $390.6M
CVRx developed an implantable technology, called Barostim neo, for the treatment of high blood pressure and heart failure.
3
Flywheel
Funding: $125.3M
Flywheel is transforming research productivity, collaboration, and reproducibility with a next generation platform for imaging and machine learning in life sciences, clinical, and academic research.
4
Nice Healthcare
Funding: $48.7M
Nice Healthcare brings healthcare services into the patient's home using a combination of in-person and virtual visits.
5
Visana Health
Funding: $37.6M
Visana Health offers a digital health program focused on improving the quality of life for women.
6
Reema Health
Funding: $16.8M
Reema Health is a technology startup transforming how people navigate the gaps between health care and social care.
7
Sansoro Health
Funding: $14.4M
Leveraging web services, Sansoro’s Emissary application provides EMR interoperability through universal application programming interfaces (APIs) and a unified data model. Once installed, this middleware can be used to connect to a wide array of third party software and hardware and will support a “build once, roll many” approach.
8
OX2 Therapeutics
Funding: $3.5M
OX2 Therapeutics is developing immunotherapy for the treatment of brain tumors based on scientific discoveries of the University of Minnesota. OX2 Therapeutics has developed a first-of-its-kind peptide that targets the immune checkpoint activation receptor CD200. The peptide activates the immune system through a mechanism that modulates the suppressive effects of the immune checkpoints CD200, PD-1/PD-L1 and CTLA4, enabling more potent antitumor response. CD200 is upregulated on tumor-associated vascular endothelial cells, creating an immunological barrier that inactivates T cells (cancer-fighting cells) as they attempt to penetrate the tumor environment. The company has received FDA clearance to conduct clinical trials of combination therapy for the treatment of high-grade glioblastoma, for which there is no curative therapy.
9
Clinician Nexus
Funding: $2.3M
Clinician Nexus provides health systems, schools, and students with a transparent, people-centered platform that facilitates better clinical rotation management, from start to finish.
10
NightWare
Funding: $1.1M
NightWare is an application on an Apple Watch that helps people suffering from traumatic nightmares to get a more restful night's sleep. It is a wearable technology that learns your sleep patterns and customizes a treatment for each individual, interrupting nightmares so you can get an uninterrupted night's sleep.
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Editor: Jason Kwon
Jason Kwon is a senior editor for MedicalStartups. He has previously covered the pharmaceutical and medical research industries for FDAnews and worked as a head of marketing for medical startup Sonic Therapeutics. Before that, he co-founded a startup consulting business for emerging entrepreneurial hubs in Asia. Jason graduated from St. Bonaventure University’s journalism school. In his free time, Jason enjoys yoga, watching movie trailers, traveling to places where he can't get cell service. You can contact Jason at jaskwon(at)medicalstartups(dot)com