Top 33 medical and healthcare startups in Chicago
Mar 05, 2026
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21
1
Funding: $2.3B
Tempus is a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.
Tempus is a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.
2
Funding: $405.3M
Oak Street Health is a network of primary care centers for adults on Medicare.
Oak Street Health is a network of primary care centers for adults on Medicare.
3
Funding: $109.8M
HealthJoy is an all-in-one healthcare guidance platform that helps employees make better decisions.
HealthJoy is an all-in-one healthcare guidance platform that helps employees make better decisions.
4
Funding: $91.3M
higi makes tracking your health simple, fun and rewarding. higi kiosks provide free screenings of your blood pressure, weight, pulse and body mass index.
higi makes tracking your health simple, fun and rewarding. higi kiosks provide free screenings of your blood pressure, weight, pulse and body mass index.
5
Funding: $85.2M
Soda provides a tech platform that allows health plans to reimburse for goods and services that aren't supported by traditional medical claims, like healthy foods, over-the-counter drugs and transportation.
Soda provides a tech platform that allows health plans to reimburse for goods and services that aren't supported by traditional medical claims, like healthy foods, over-the-counter drugs and transportation.
6
Funding: $84M
nOCD offers a mobile mental health app. Our goal is to revolutionize OCD treatment.
nOCD offers a mobile mental health app. Our goal is to revolutionize OCD treatment.
7
Funding: $78.2M
We provide neurodegenerative disease patients with expert MDs and 24/7 wrap around care, no matter where you live in the US
We provide neurodegenerative disease patients with expert MDs and 24/7 wrap around care, no matter where you live in the US
8
Funding: $58.8M
Vivante makes a digital program for digestive health and disease called GIThrive that includes, among other tools, a 24-7 support line to a gastrointestinal care team.
Vivante makes a digital program for digestive health and disease called GIThrive that includes, among other tools, a 24-7 support line to a gastrointestinal care team.
9
Funding: $58.2M
TimeDoc helps healthcare organizations manage and coordinate care for their chronic disease patients.
TimeDoc helps healthcare organizations manage and coordinate care for their chronic disease patients.
10
Funding: $55.5M
Waltz Health develops search engine that pharmacies can provide to their consumers that utilizes data from different drug discount programs to find lower-cost medications. It plans to use the capital to scale the business, hire new team members and invest in product development.
Waltz Health develops search engine that pharmacies can provide to their consumers that utilizes data from different drug discount programs to find lower-cost medications. It plans to use the capital to scale the business, hire new team members and invest in product development.
11
Funding: $54.4M
KeyCare is a virtual care platform powered by Epic created to support progressive health systems.
KeyCare is a virtual care platform powered by Epic created to support progressive health systems.
12
Funding: $50M
Avaneer Health leverages blockchain and FHIR technologies to allow for secure data exchange between healthcare organizations.
Avaneer Health leverages blockchain and FHIR technologies to allow for secure data exchange between healthcare organizations.
13
Funding: $43.1M
Opternative builds online eye exam, the most convenient way to get a prescription from an ophthalmologist for contacts and glasses. The exam can be taken from anywhere, at any time, and a doctor issued prescription can be used to shop everywhere. Eye exams for glasses and contact prescriptions are just the beginning. We envision a world where technology allows patients and doctors to connect to make all aspects of vision care more convenient, accessible and even fun!
Opternative builds online eye exam, the most convenient way to get a prescription from an ophthalmologist for contacts and glasses. The exam can be taken from anywhere, at any time, and a doctor issued prescription can be used to shop everywhere. Eye exams for glasses and contact prescriptions are just the beginning. We envision a world where technology allows patients and doctors to connect to make all aspects of vision care more convenient, accessible and even fun!
14
Funding: $41.9M
Atraverse Medical offers a product development for left-heart access technology to simplify workflows and improve patient outcomes.
Atraverse Medical offers a product development for left-heart access technology to simplify workflows and improve patient outcomes.
15
Funding: $40M
Zarminali Health transforms pediatric care by building multispecialty pediatric group that provides modern, seamlessly coordinated care.
Zarminali Health transforms pediatric care by building multispecialty pediatric group that provides modern, seamlessly coordinated care.
16
Funding: $32.3M
Blueprint aids mental health clinicians in providing personalized results through measurement-based care.
Blueprint aids mental health clinicians in providing personalized results through measurement-based care.
17
Funding: $30.5M
Upfront Healthcare is a developer of patient navigation platform designed to combine analytics, dynamic content, and automated outreach.
Upfront Healthcare is a developer of patient navigation platform designed to combine analytics, dynamic content, and automated outreach.
18
Funding: $22.2M
First Stop Health provides telemedicine services to consumers and employers. Through its nationwide network of physicians we treat members' everyday health issues over the phone and online, any time.
First Stop Health provides telemedicine services to consumers and employers. Through its nationwide network of physicians we treat members' everyday health issues over the phone and online, any time.
19
Funding: $20M
Praia Health is a modern consumer platform for health systems that transforms the delivery of tailored health solutions on a large scale.
Praia Health is a modern consumer platform for health systems that transforms the delivery of tailored health solutions on a large scale.
20
Funding: $18.2M
Dina Care provides an online patient engagement platform designed to connect patients with healthcare service providers.
Dina Care provides an online patient engagement platform designed to connect patients with healthcare service providers.
21
Funding: $17.2M
Level Ex explores medical simulations for astronauts and building tools that show how low gravity affects the human body, and how medical issues can be addressed during spaceflight.
Level Ex explores medical simulations for astronauts and building tools that show how low gravity affects the human body, and how medical issues can be addressed during spaceflight.
22
Funding: $15.1M
Cardiosense offers a physiological waveform AI platform to develop predictive biomarkers for the detection and treatment of disease.
Cardiosense offers a physiological waveform AI platform to develop predictive biomarkers for the detection and treatment of disease.
24
Funding: $11.8M
AMOpportunities connects international medical students and graduates with U.S. physicians and institutions for clinical experiences.
AMOpportunities connects international medical students and graduates with U.S. physicians and institutions for clinical experiences.
25
Funding: $6.4M
MetaMe Health is committed to developing FDA-approved prescription digital therapeutics for the treatment of gastrointestinal conditions.
MetaMe Health is committed to developing FDA-approved prescription digital therapeutics for the treatment of gastrointestinal conditions.
26
Funding: $4.4M
ImmersiveTouch is a leader in simulation based surgical training and exploration. ImmersiveTouch simulators ‘immerse’ surgeons in a digitally replicated operating environment with high-fidelity 3D virtual anatomies and haptic instrument replicates
ImmersiveTouch is a leader in simulation based surgical training and exploration. ImmersiveTouch simulators ‘immerse’ surgeons in a digitally replicated operating environment with high-fidelity 3D virtual anatomies and haptic instrument replicates
27
Funding: $4M
Cofactor AI is a financial intelligence platform for the healthcare industry that helps to successfully appeal claims denials.
Cofactor AI is a financial intelligence platform for the healthcare industry that helps to successfully appeal claims denials.
28
Funding: $3.8M
Oxalo Therapeutics develops a first-of-its-kind peptide-based drug to prevent kidney stones.
Oxalo Therapeutics develops a first-of-its-kind peptide-based drug to prevent kidney stones.
29
Funding: $3.4M
SkinIO is helping people prevent skin cancer by providing a service that allows them to regularly monitor their skin with the help of artificial intelligence and licensed dermatologists. Users can take photos with their smartphone of their skin and lesions, and upload them to a database through SkinIO’s app.
SkinIO is helping people prevent skin cancer by providing a service that allows them to regularly monitor their skin with the help of artificial intelligence and licensed dermatologists. Users can take photos with their smartphone of their skin and lesions, and upload them to a database through SkinIO’s app.
30
Funding: $1M
AI-powered ophthalmic image management system that helps to detect 54 pathologies and 49 pathological signs on OCT scans.
AI-powered ophthalmic image management system that helps to detect 54 pathologies and 49 pathological signs on OCT scans.
31
Funding: $1M
Altris.AI, a health tech company, develops ophthalmology deep learning platform for retinal diseases detection from Optical Coherence Tomography (OCT) scans or Fundus images at early, asymptomatic stages by learning from a large dataset of clinical cases.
Altris.AI, a health tech company, develops ophthalmology deep learning platform for retinal diseases detection from Optical Coherence Tomography (OCT) scans or Fundus images at early, asymptomatic stages by learning from a large dataset of clinical cases.
32
Orka is an AI-powered hearing healthcare company that uses innovative technology and user insights to create human-centered and accessible hearing aids.
33
Health Navigation 360 offers a 360° view of patient experience and systematically and sensitivity increases patient satisfaction and staff morale in real time.
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