Top 16 medical and healthcare startups in Italy
Mar 28, 2026
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12
1
Funding: $206.3M
AAVantgarde Bio is a clinical-stage biotechnology company that develops retinal disease gene therapies. One of its drugs is intended at patients with Stargardt disease, a leading cause of vision loss in children and young adults. By delivering the full-length ABCA4 protein, AAVantgarde hopes that it can address the root cause of this eye condition. Another asset is for patients with retinitis pigmentosa associated with Usher syndrome - rare genetic disease that affects both hearing and vision. AAVantgarde says that its proprietary technology has demonstrated high transduction, protein expression and safety for both Stargardt and Usher 1B.
AAVantgarde Bio is a clinical-stage biotechnology company that develops retinal disease gene therapies. One of its drugs is intended at patients with Stargardt disease, a leading cause of vision loss in children and young adults. By delivering the full-length ABCA4 protein, AAVantgarde hopes that it can address the root cause of this eye condition. Another asset is for patients with retinitis pigmentosa associated with Usher syndrome - rare genetic disease that affects both hearing and vision. AAVantgarde says that its proprietary technology has demonstrated high transduction, protein expression and safety for both Stargardt and Usher 1B.
2
Funding: $220M
MMI (Medical Microinstruments) produces the world's most precise surgical robot, Symani with smallest wristed instruments. It allows surgeons to operate on lymphatic vessels smaller than 0.5 millimeters, while the physician monitors the procedure on a screen with a raised outline. The system is designed to perform microsurgical anastomoses, suture and ligate blood vessels, lymphatic ducts, and nerves, as well as for soft tissue dissection during open surgery. Symani is successfully used in neurosurgery, breast reconstruction after cancer, and lymphatic drainage procedures. MMI has also received FDA approval for clinical trials of surgical treatment for Alzheimer's disease.
MMI (Medical Microinstruments) produces the world's most precise surgical robot, Symani with smallest wristed instruments. It allows surgeons to operate on lymphatic vessels smaller than 0.5 millimeters, while the physician monitors the procedure on a screen with a raised outline. The system is designed to perform microsurgical anastomoses, suture and ligate blood vessels, lymphatic ducts, and nerves, as well as for soft tissue dissection during open surgery. Symani is successfully used in neurosurgery, breast reconstruction after cancer, and lymphatic drainage procedures. MMI has also received FDA approval for clinical trials of surgical treatment for Alzheimer's disease.
3
Funding: $209.8M
MMI (Medical Microinstruments Inc) is a developer of novel robotic solutions for unmet medical needs.
MMI (Medical Microinstruments Inc) is a developer of novel robotic solutions for unmet medical needs.
4
Funding: €39M
Enthera's mission is to find new therapeutic approaches to treat diabetes and related gastrointestinal complication (enteropathy), as well as other intestinal disorders sharing the same biological pathway.
Enthera's mission is to find new therapeutic approaches to treat diabetes and related gastrointestinal complication (enteropathy), as well as other intestinal disorders sharing the same biological pathway.
5
Funding: $35.6M
We design and develop the world's smallest and most accurate wearable devices for medical research and epilepsy management.
We design and develop the world's smallest and most accurate wearable devices for medical research and epilepsy management.
6
Funding: $6.9M
Clinically validated and beautifully designed digital medicine and digital therapeutic solutions (DTx)
Clinically validated and beautifully designed digital medicine and digital therapeutic solutions (DTx)
7
Funding: €2.2M
Euleria is a provider of digital rehabilitation devices and solutions for better recovery of patients.
Euleria is a provider of digital rehabilitation devices and solutions for better recovery of patients.
8
Funding: €1.8M
Soundsafe Care develops robotic device that utilizes ultrasound technology for the treatment of liver cancer. Its focused ultrasound provides a non-invasive and drug-free alternative to radiation therapy, reducing complications and hospitalization costs. Using advanced imaging and automation technologies, the device improves treatment precision and reduces intervention time. The company has developed proprietary software that automates the procedure, making it precise, reproducible and intuitive for the physician. Computer vision and robotics enable tracking and compensation of any potential movement of the therapeutic target, ensuring safety in various surgical settings and anatomical areas. Furthermore, therapy planning and automation speed up the treatment process.
Soundsafe Care develops robotic device that utilizes ultrasound technology for the treatment of liver cancer. Its focused ultrasound provides a non-invasive and drug-free alternative to radiation therapy, reducing complications and hospitalization costs. Using advanced imaging and automation technologies, the device improves treatment precision and reduces intervention time. The company has developed proprietary software that automates the procedure, making it precise, reproducible and intuitive for the physician. Computer vision and robotics enable tracking and compensation of any potential movement of the therapeutic target, ensuring safety in various surgical settings and anatomical areas. Furthermore, therapy planning and automation speed up the treatment process.
9
Funding: €1.5M
Chino.io is a GDPR and HIPAA compliant Backend and Database as a Service for health data and applications.
Chino.io is a GDPR and HIPAA compliant Backend and Database as a Service for health data and applications.
10
Funding: €1.3M
BrainDTech represents a disruptive approach to brain disease diagnosis because it detects a signal (MicroRNA in microvesicles) released by microglia years before any clinical manifestation
BrainDTech represents a disruptive approach to brain disease diagnosis because it detects a signal (MicroRNA in microvesicles) released by microglia years before any clinical manifestation
11
Sensoria developed a technology platform comprising novel textile sensors, cloud and mobile software that enable a wide range of remote patient monitoring applications
13
Anbition Srl is developing new molecules and technologies for treating or diagnosing angiogenesis-related diseases
14
MEDICAL-NOTE is a medical app and software company born in 2018 whose purpose is to simplify daily tasks for surgeons, optimize preoperative planning and minimize complications through digital solutions.
15
Takis main focus is the development of therapeutic cancer vaccines against tumor antigens which play a role in tumor development and maintenance.
16
Huvant is a phygital medical simulation platform that supports pre-operative planning and device validation using realistic pathological anatomies. Complex procedures involve a high level of uncertainty. Understanding in advance how a strategy or a device will perform in real-life conditions helps optimize clinical outcomes, timelines and patient safety. Huvant’s platform reduces this uncertainty by enabling clinicians and medical companies to simulate procedures and test devices before reaching the patient, within a controlled and realistic environment. Clinicians can explore access pathways, analyze critical structures (landmarks, volumes, etc.), and compare different operative strategies. This allows the entire team to align around a shared plan that is safer and more predictable.
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